Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 1.

Molecular regulators of hepatic polyploidy associated with NAFLD/HCC in animal model

Animal model Nuclear ploidy Cellular ploidy Molecular mechanism NAFLD/HCC symptoms References
E2f8 LKO mouse Decreased Decreased Endocyclic gene regulation Chen et al., 2012
Cdk1 LKO mouse Increased DNA re-replication due to an increase in Cdk2/cyclin A2 activity Diril et al., 2012
Cdk1 LKO mouse Increased Decreased DNA re-replication regulation Blood ALT, bilirubin, and ALP levels increased
Hepatic fibrosis area increased
Dewhurst et al., 2020
Ssu72 LKO mouse Increased Decreased Rb-E2F signaling pathway Serum ALT and AST levels increased
Hepatic fat accumulation increased
Hepatic fibrosis area increased
Kim et al., 2016
Mir-122 germline
KO mouse
Decreased Decreased Cytokinesis regulation Hepatic steatosis increased
Hepatic fibrosis promoted
Hsu et al., 2016
Yap LKO mouse Decreased Akt-Skp2-p27/FoxO axis Liver tumorigenesis enhanced Zhang et al., 2017
Lis1 LKO mouse Increased Decreased Hepatic steatosis induced and liver tumorigenesis accelerated Li et al., 2018
RORα LKO mouse Increased No change E2F7/E2F8 activated Hepatic steatosis increased
Hepatic collagen deposition increased
Kim et al., 2022

LKO, liver-specific knockout; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; Yap, yes-associated protein; Skp2, S-phase kinase-associated protein 2; LIS1, lissencephaly 1.

Biomolecules & Therapeutics 2022;30:391~398
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