Fig. 1. CKD-581 increases acetylated proteins and suppresses cell proliferation in hematologic cancer cells. (A) The chemical structure of CKD-581. (B) Acetylation of histone H3, H4 and tubulin. MM.1S cells were treated with 30-1000 nM CKD-581 or SAHA for 6 h. Acetylation of proteins was analyzed by immunoblottings. (C) Inhibitory effects of CKD-581 and SAHA on cell viabilities of hematologic cancer cell lines. All data represent mean ± SEM of at least three independent experiments.
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