Fig. 6. Effect of sinapic acid (SA) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice through the inhibition of REV-ERB α. (A, B) After 5 days of SA and SR8278 (SR) treatment with MPTP, the motor functions of the mice were examined using the rotarod and pole tests (n=6). (C, D) The protein expression of tyrosine hydroxylase (TH) and REV-ERB α was measured by western blot after treatment with MPTP, SA and SR (n=6). (E, F) The ATP content and glutamate dehydrogenase (GDH) activity were measured using a commercially available assay kit to examine mitochondrial function (n=6). Full-length blots are shown in the supplementary information. The results are presented as the mean ± SEM. *p<0.05 compared to the control group, #p<0.05 compared to the MPTP group, $p<0.05 compared to the SA group.
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