Fig. 3. Effect of sinapic acid (SA) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. (A) Experimental procedure and drug administration scheme. (B, C) After 5 days of SA treatment with or without MPTP, the motor functions of the mice were examined using the rotarod and pole tests (n=6). (D, E) The protein expression of tyrosine hydroxylase (TH) and REV-ERB was measured by western blot after treatment with both MPTP and SA (n=6). (F, G) The ATP content and glutamate dehydrogenase (GDH) activity were measured using a commercially available assay kit to examine mitochondrial function (n=6). Full-length blots are shown in the supplementary information. The results are presented as the mean ± SEM. *p<0.05 compared to the control group, #p<0.05 compared to the MPTP group.
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