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Fig. 5. Effects of the FDA-approved drugs on the SARS-CoV-2 N protein and S protein production. Vero E6 cells were infected with a 0.1 MOI of SARS-CoV-2 in 12-well plates and then treated with 0.1% DMSO, atovaquone (10 µM) or abiraterone acetate (10 µM) at 3 h after virus infection. The cells were cultured for 48 h in DMEM media containing 2% FBS. Confocal images were analyzed using a Carl Zeiss LSM710 microscope after staining with anti-SARS-CoV S Ab (A) or anti-SARS-CoV N mAb (B) and then Alexa Fluor 488-conjugated secondary antibody. Scale bar, 20 µm.
Biomolecules & Therapeutics 2022;30:427~434 https://doi.org/10.4062/biomolther.2022.037
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