Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 1.

Stimulators and inhibitors of mitochondrial biogenesis in animal DCM models

Types DCM models Mechanisms References
Stimulators
Melatonin T1DM STZ injection mice SIRT3/Mst1 Yu et al., 2021
T2DM High-fat diet and STZ injection rats SIRT6, AMPK-PGC-1α-AKT Zhang et al., 2017
Resveratrol T2DM High-fat diet and STZ injection rats SIRT1-PGC-1α deacetylation Fang et al., 2018
SIRT1 deletion mice SIRT1-PGC-1α deacetylation Ma et al., 2017
Salidroside T2DM High-fat and STZ-injection mice SIRT3, AMPK/AKT/PGC-1α-TFAM Li et al., 2021b
Pterostillbene T1DM High-glucose diet rats AMPK/NRF2/HO-1/PGC-1α Kosuru et al., 2018
miR-144 T1DM STZ-injection mice Rac-1/AMPK/PGC-1α Tao et al., 2020
BH4 T2DM OLETF rats CaMKK2-AMPK/CAMP/CREB/PGC-1α Kim et al., 2020
Exercise
Resistance T2DM OLETF rats UCP2/UCP3 Ko et al., 2018
Moderate T2DM Db/db mice CXC3 Veeranki et al., 2016
Ensurance T2DM Db/db mice PGC-1α-AKT Wang et al., 2015
Inhibitors
ADMA T2DM High-fat and STZ injection rats PGC-1α phosphorylation and acetylation Xiong et al., 2020
T1DM STZ injection rats NO/PGC-1α Xiong et al., 2021

T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; STZ, streptozotocin; OLETF, Otsuka long-evans Tokushima fatty; BH4, tetrahydrobiopterin; ADMA, asymmetric dimethylarginine.

Biomolecules & Therapeutics 2022;30:399~408 https://doi.org/10.4062/biomolther.2021.192
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