Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 7. Schematic diagram of the proposed mechanism of anti-proliferative activity of urushiol V. Urushiol V decreased FoxM1 expression and consequently inhibited cell proliferation of SW480 colon cancer cells. 5-FU exerts an antitumor activity by blocking the activity of thymidylate synthase (TS), an enzyme essential for DNA replication. However, prolonged use of 5-FU leads to drug resistance through increasing expressions of FoxM1 and TS. Urushiol V suppressed expressions of FoxM1 and TS, and enhanced anti-proliferative activity of 5-FU against resistant colon cancer cells (SW480/5-FUR).
Biomolecules & Therapeutics 2022;30:257~264
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