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Fig. 4. BT regulates SREBP1 and PPARα/γ expression in chronic EtOH-treated mice. (A) Representative Western blotting analysis for expressions of SREBP1, FASN, PPARα, PPARγ, lipin1, lipin2 and PGC-1α; RT-PCR analysis for expressions of SREBP1. (B) Immunohistochemical staining of SREBP1 present in 100× and 400× magnification. (C) Immunohistochemical staining of lipin1 present in 100× and 400× magnification and immunofluorescence staining of lipin2 present in 100× magnification. Densitometric values were normalized against GAPDH. ###p<0.001, ##p<0.01, #p<0.05 vs normal group, *p<0.05, **p<0.01, ***p<0.001 vs EtOH group, ns, not significant. All histograms represent the mean ± SD of at least three independent assays.
Biomolecules & Therapeutics 2022;30:246~256 https://doi.org/10.4062/biomolther.2021.136
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