Fig. 3. Therapeutic efficacy of BEZ-235 on cell viability and PI3K/AKT signaling. (A) MIA PaCa-2 and PANC-1 cells were treated with BEZ-235 (0.01-5 μM) for 72 h, and cell viability was measured using the MTS assay. (B) Pancreatic cancer cells (MIA PaCa-2 and PANC-1) were treated with BEZ-235 (0.01, 0.05, and 0.1 μM) for 2 h. The expressions of p-AKT, p-P70 S6K, and p-ERK levels were determined using western blotting. Data are presented as the means ± SD (**p<0.01 and ***p<0.001).
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