Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Download original image
Fig. 6. Diagram of shikonin-induced ER stress signaling resulting in apoptosis. Shikonin induces the expression of ER stress-related proteins, such as GRP78 and CHOP, and releases Ca2+, thereby causing 5-FU-resistant SNU-C5 colorectal cancer cells to undergo apoptosis. The calcium chelator, EGTA, and the ER stress inhibitor, TUDCA, protected cells against ER stressed-apoptotic cell death.
Biomolecules & Therapeutics 2022;30:265~273
© Biomolecules & Therapeutics