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Table. 2.

Table 2 Effects of adiponectin on various types of cells present in the skin

Cell Effects of Adiponectin on cells References
Keratinocyte Promotes cell proliferation and migration via ERK activation Shibata et al., 2012
Effects on differentiation through enhancing lipid synthesis Hong et al., 2019
Anti-photoaging effect via downregulation of p38 and JNK/SAPK MAPK signaling Kim et al., 2016
Melanocyte Full-length adiponectin inhibits melanogenesis via AMPK activation Bang et al., 2017
Globular adiponectin stimulates melanogenesis via AMPK-p38 MAPK, CREB signaling Kim et al., 2018
Fibroblast Increasing HA and collagen production in a concentration-dependent manner and HA synthases 1,2,3 gene expression Yang et al., 2013
Attenuating CTGF-induced keloid fibroblast progression by inhibiting AMPK, p38 MAPK, ERK signaling Iwayama et al., 2012
Decreasing the activation of fibroblasts and reversing the activation phenotype of systemic sclerosis fibroblasts Marangoni et al., 2017
Macrophage Suppressing macrophage proliferation Hui et al., 2015
Activating M2 instead of M1 differentiation Tsatsanis et al., 2005; Park et al., 2007
Dendritic cell Role in DC differentiation remains controversial Tsang et al., 2011; Jung et al., 2012; Li et al., 2012
Alters DC phenotype Li et al., 2012
Alters DC function to reduce allogenic T-cell proliferation Tsang et al., 2011; Li et al., 2012
Neutrophil Full-length adiponectin blocks neutrophil phagocytosis Wensveen et al., 2015
Inhibits neutrophil apoptosis Rossi and Lord, 2013
Eosinophil Negatively regulates recruitment of eosinophils Rossi and Lord, 2013
Eotaxin-enhanced adhesion is inhibited by adiponectin pretreatment Yamamoto et al., 2013
Eotaxin-directed chemotactic responses are diminished
Natural Killer (NK) cell Still controversial Takemura et al., 2007; Shibata et al., 2015
Τ lymphocytes Suppresses TNF-α, IL-17, IL-22 secretion Takahashi and Iizuka, 2012; Jasinski-Bergner et al., 2017
Inhibits IL-17 producing activation of γδ T cells Shibata et al., 2015
Biomolecules & Therapeutics 2022;30:221~231 https://doi.org/10.4062/biomolther.2021.089
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