Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 1.

Table 1 Adiponectin receptors

Receptor Affinity toward adiponectin Expression site Feature
AdipoR1 High affinity toward globular adiponectin Ubiquitous Integral membrane protein
Can bind to full-length adiponectin Especially skeletal muscle and liver
AdipoR2 Intermediate affinity toward both globular adiponectin and full-length adiponectin Restricted to liver Integral membrane protein
T-cadherin Binds to the MMW and HMW forms of adiponectin Endothelial cell Interacts with eukaryotic post-translational modified adiponectin
Smooth muscle cell
Attached to the plasma membrane by glycosyl phosphatidylinositol anchor Does not interact with globular or bacterial-produced adiponectin
Biomolecules & Therapeutics 2022;30:221~231
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