Fig. 7. Distribution of time-dependent inhibitor positive and negative compounds among Novartis (A) marketed drugs and (B) new chemical entities (i.e., drug candidates). The dark gray fraction represents strong (“high”) reversible inhibition (
Zimmerlin et al., 2011). Reprinted from Drug Metab. Dispos., Vol. 39, Zimmerlin, A., Trunzer, M. and Faller, B., CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs, pages 1039-1046 (
Zimmerlin et al., 2011), Copyright (2011), with permission from American Society for Pharmacology and Experimental Therapeutics.
