
Table 6 P450s as drug targets
Currently in clinical practice |
P450 5A1 (anti-platelet drugs, inhibit thromboxane production) |
Pictamide |
Riogrel |
Ozagrel |
Furegrelate |
P450 19A1 (breast and other hormonal cancers) |
Exemestane |
Anastrozole |
Letrozole |
P450 17A1 (prostate cancer) |
Abiraterone |
P450 11B1 (Cushing’s disease) |
Mifepristone |
P450 51 (anti-fungal, inhibit fungal P450s) |
Ketoconazole |
Fluconazole |
Itraconazole |
Vorconazole |
Posaconazole |
Isavuconazole |
Mifepristone |
Discovery and development programs |
P450 4A11 (hypertension) |
P450 11A1 (prostate cancer) |
P450 11B2 (hypertension) |
P450 24A1 (increase vitamin D3 levels) |
P450 26A1 (increase vitamin A levels) |
P450 26B1 (increase vitamin A levels) |