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Table. 6.

Table 6 P450s as drug targets

Currently in clinical practice
P450 5A1 (anti-platelet drugs, inhibit thromboxane production)
Pictamide
Riogrel
Ozagrel
Furegrelate
P450 19A1 (breast and other hormonal cancers)
Exemestane
Anastrozole
Letrozole
P450 17A1 (prostate cancer)
Abiraterone
P450 11B1 (Cushing’s disease)
Mifepristone
P450 51 (anti-fungal, inhibit fungal P450s)
Ketoconazole
Fluconazole
Itraconazole
Vorconazole
Posaconazole
Isavuconazole
Mifepristone
Discovery and development programs
P450 4A11 (hypertension)
P450 11A1 (prostate cancer)
P450 11B2 (hypertension)
P450 24A1 (increase vitamin D3 levels)
P450 26A1 (increase vitamin A levels)
P450 26B1 (increase vitamin A levels)
Biomolecules & Therapeutics 2022;30:1~18 https://doi.org/10.4062/biomolther.2021.102
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