Table 5 Examples of sensitive
| P450 Enzymes |
Sensitive substrates | Substrates with narrow therapeutic range |
|---|---|---|
| 1A2 | Alosetron, caffeine, duloxetine, melatonin, ramelteon, tacrin, tizanidine | Theophylline, tizanidine |
| 2B6 | Bupropion, efavirenz | |
| 2C8 | Repaglinide | Paclitaxel |
| 2C9 | Celecoxib | Warfarin, phenytoin |
| 2C19 | Clobazam, lansoprazole, omeprazole, (S)-mephenytoin | (S)-Mephenytoin |
| 3A | Alfentanil, aprepitant, budesonide, buspirone, conivaptan, darifenacin, darunavir, dasatinib, dronedarone, eletriptan, eplerenone, everolimus, felodipine, indinavir, fluticasone, lopinavir, lovastatin, lurasidone, maraviroc, midazolam, nisoldipine, quetiapine, sqquinavir, sildenafile, simvastatin, sirolimus, tolvaptan, tipranair, triazolam, ticagrelor, vardenafil | Alfentanil, astemizole, cisapride, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, terfenadine |
| 2D6 | Atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxsine | Thioridazine, pimozide |