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Fig. 3. Fractions of small molecule drugs approved by US FDA in 2015-2020 metabolized by individual enzymes (Bhutani et al., 2021). UGT: uridine glucuronyl transferase; FMO, flavin-containing monooxygenase; AO, aldehyde oxidase. Reprinted from J. Med. Chem., Vol. 64, Bhutani, P., Joshi, G., Raja, N., Bachhav, N., Rajanna, P. K., Bhutani, H., Paul, A. T. and Kumar, R., US FDA approved drugs from 2015-June 2020: a perspective, pages 2339-2381 (Bhutani et al., 2021), Copyright (2021), with permission from American Chemical Society.
Biomolecules & Therapeutics 2022;30:1~18
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