Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 15. Formulae used to estimate in vivo inhibition parameters from in vitro measurements (Obach et al., 2005). AUC: area under the curve; I, inhibitor (in vitro or plasma concentration); CL: clearance; fm(CYP), fraction of the clearance of the drug catalyzed by a particular P450 enzyme (CYP).
Biomolecules & Therapeutics 2022;30:1~18
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