Fig. 11. Part of the structure of P450 3A4 bound to two molecules of ketoconazole (Protein Data Bank 2V0M). The two molecules of ketoconazole are indicated in red/orange, and the heme is in magenta. The mesh indicates ketoconazole electron density (
Ekroos and Sjögren, 2006). Note the proximity of an imidazole nitrogen of one ketoconazole molecule to the heme iron atom (magenta sphere). The F, F´, G, G´, and I helices are shown. Reprinted from Proc. Natl. Acad. Sci. U.S.A., Vol. 103, Ekroos, M. and Sjögren, T., Structural basis for ligand promiscuity in cytochrome P450 3A4, pages 13682-13687 (
Ekroos and Sjögren, 2006), Copyright (2006), with permission from National Academy of Sciences.
