Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 11. Part of the structure of P450 3A4 bound to two molecules of ketoconazole (Protein Data Bank 2V0M). The two molecules of ketoconazole are indicated in red/orange, and the heme is in magenta. The mesh indicates ketoconazole electron density (Ekroos and Sjögren, 2006). Note the proximity of an imidazole nitrogen of one ketoconazole molecule to the heme iron atom (magenta sphere). The F, F´, G, G´, and I helices are shown. Reprinted from Proc. Natl. Acad. Sci. U.S.A., Vol. 103, Ekroos, M. and Sjögren, T., Structural basis for ligand promiscuity in cytochrome P450 3A4, pages 13682-13687 (Ekroos and Sjögren, 2006), Copyright (2006), with permission from National Academy of Sciences.
Biomolecules & Therapeutics 2022;30:1~18
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