Table 2 Biomedical activity and application of glycerolipids
Subclass | Name | Activity | Medical application | Ref. |
---|---|---|---|---|
Monoacylglycerol | Monocaprylate | Formation of transient or permanent pores in the membrane | Antimicrobial | Hyldgaard |
MonolaurinMoncaprin | Bactericidal activity against H. pylori | Infectious disease | Bergsson |
|
Monoolein | Antimicrobial activity against S. aureus and E. coli | Antimicrobial | Jumina |
|
MAG-DHA | Downregulation of NF-kB and upregulation of PTEN | Non-small cell lung cancer | Morin and Fortin, 2017 | |
Diacylglycerol | Monogalactosyl diacylglycerol | Inhibition of CD31 positive tumor blood vessel growth. | Colon cancer | Maeda |
1,3-Diacylglycerol | Increasing oxidation of fatty acid and suppressing chylomicron formation | Obesity and insulin resistance | Saito |
|
Triacylglycerol | Medium-chain triglyceride | Suppression of IL-6, iNOS, cyclooxygenase-2 and IL-10 and activation of NF-kB and p38 MAPK pathways | Insulin resistance | Geng |
Medium-chain triglyceride | Metabolized to ketone bodies to the brain | Neurological and metabolic disorders | Augustin |
|
Tricaprilin (AC-1202) | Reducing oxidative damage and improvement of respiration rate in brain | Alzheimer’s disease | Henderson |