Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 1.

Biomedical activity and application of fatty acids

Class Name Activity Application Ref.
Short-chain fatty acids Propionic acid Immunomodulatory effect on mature dendritic cells Anti-inflammatory activity Nastasi et al., 2015
Enhance regulatory T cell metabolism and function Multiple sclerosis Duscha et al., 2020
Alteration of bone marrow hematopoiesis Allergic airway disease Trompette et al., 2014
Butyric acid Microencapsulated butyric acid for regulation of microbiota (ButyRose) Inflammatory bowel disease Facchin et al., 2020
Enhanced epithelial barrier function through IL-10 receptor Inflammatory bowel disease Zheng et al., 2017
Alleviates mouse colitis by regulating gut microbiota dysbiosis Inflammatory bowel disease Dou et al., 2020
Regulation of intestinal homeostasis through actin-associated protein synaptopodin Inflammatory bowel disease Wang et al., 2020
Intestinal macrophage regulation via histone deacetylase inhibition Inflammatory bowel disease Chang et al., 2014
Pentanoic acid Inducing IL-10 production in lymphocytes by reprogramming their metabolic activity Experimental autoimmune encephalomyelitis Luu et al., 2019
Medium-chain fatty acids Decanoic acid Synergistic action against AMPA receptors and seizures with perampanel Seizure control Augustin et al., 2018a
Inhibition of glutamate-induced currents derived from various types of AMPA receptor Seizure control Chang et al., 2016
Long-chain fatty acids α-linolenic acid Promoting bioconversion and subsequent oxylipin formation High fat diet induced Insulin resistance Fan et al., 2020
Enhanced production of oxylipins in M1 macrophage Anti-inflammatory activity Pauls et al., 2018
Activation of alternatively activated macrophages via oxylipin profile change Anti-inflammatory activity Pauls et al., 2020
Modulation of phagocytosis and endosomal pathways of extracellular Tau in microglia Alzheimer’s disease Desale and Chinnathambi, 2021
Alleviates dextran sulfate sodium-induced ulcerative colitis in mice Inflammatory bowel disease Kim et al., 2020
Eicosapentaenoic acid Improvement of hepatic metabolism and reduces inflammation in mice and HepG2 cells Nonalcoholic fatty liver disease Albracht-Schulte et al., 2019
Inhibition NLRP3 inflammasome activation Acute cerebral infarction (ACI) Mo et al., 2020
Docosahexaenoic acid Enhanced M2 macrophage polarization via the p38 signaling pathway and autophagy Chronic inflammation Kawano et al., 2019
Modulate monocyte inflammatory response Chronic inflammation So et al., 2021
Biomolecules & Therapeutics 2021;29:465~482 https://doi.org/10.4062/biomolther.2021.107
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