Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 5.

Biomedical activity and application of saccharolipids

Subclass Name Activity Medical application Ref.
Lipid A LPS Upregulation of pro-inflammatory cytokines Wound healing Kostarnoy et al., 2013
Generate tolerogenic dendritic cells to exhaust effector CD4 T cells Experimental autoimmune encephalomyelitis Zhou et al., 2014
Increase endogenous TNF-α expression Cancer Goto et al., 1996
Upregulation of MHC molecule on GSCs Cancer Han et al., 2017
Monophosphoryl lipid A TLR4 agonist Vaccine adjuvant Saito et al., 2010
Enhancing CD4 T cell activation and initial clonal expansion Vaccine adjuvant Thompson et al., 2005
Biomolecules & Therapeutics 2021;29:465~482
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