Table. 5.

Table 5 Biomedical activity and application of saccharolipids

Subclass	Name	Activity	Medical application	Ref.
Lipid A	LPS	Upregulation of pro-inflammatory cytokines	Wound healing	Kostarnoy et al., 2013
		Generate tolerogenic dendritic cells to exhaust effector CD4 T cells	Experimental autoimmune encephalomyelitis	Zhou et al., 2014
		Increase endogenous TNF-α expression	Cancer	Goto et al., 1996
		Upregulation of MHC molecule on GSCs	Cancer	Han et al., 2017
	Monophosphoryl lipid A	TLR4 agonist	Vaccine adjuvant	Saito et al., 2010
		Enhancing CD4 T cell activation and initial clonal expansion	Vaccine adjuvant	Thompson et al., 2005

Biomolecules & Therapeutics 2021;29:465~482 https://doi.org/10.4062/biomolther.2021.107

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