Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 4.

Biomedical activity and application of sphingolipids

Subclass Name Activity Medical application Ref.
Ceramide C6 ceramide Increasing vincristine sensitivity via AMP activated protein kinase–p53 signaling Colon cancer, pancreatic cancer Chen et al., 2015
Oxidized graphene nanoparticles as a delivery system for the pro-apoptotic C6 ceramide Cervical cancer Suhrland et al., 2019
Graphene oxide nanoparticle delivery system enhance anti-cancer activity of C6 ceramide Hepatocellular carcinoma Wang et al., 2019
Liposomal short-chain C6 ceramide induces potent anti-osteosarcoma activity Osteosarcoma Zhai et al., 2015
Sphingo-myelin Sphingomyelin Sphingomyelin-based nanosystems (SNs) for the anticancer miRNA therapeutics Colon cancer Nagachinta et al., 2020
Site-activated drug releasing lipid-iron nanoparticle Cancer Medina et al., 2020
Engineered liposomes sequester bacterial exotoxins and protect from invasive infections Antibiotics Henry et al., 2015
Specific drug release lipid nanoparticles at infection sites Antibiotics Zhang et al., 2021
Glyco-sphingolipid N-octanoyl-glucosylceramide Improvement of doxorubicin delivery and efficacy in solid tumors Squamous cell carcinoma, Melanoma van Lummel et al., 2011
Improvement of efficacy of liposomal doxorubicin Lobular breast carcinoma van Hell et al., 2013
Formation of transient micro-channels within the cell membrane Uterine sarcoma Zalba et al., 2020
α-Galactosyl-ceramide (α-GalCer) Antigen-presenting cell immunotherapy by the activation of endogenous iNKT cells Non-small cell lung cancer Toyoda et al., 2020
mRNA nanovaccine with α-GalCer induces antitumor immunity by NKT cells Melanoma Verbeke et al., 2019
Biomolecules & Therapeutics 2021;29:465~482
© Biomolecules & Therapeutics