Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Table. 3.

Biomedical activity and application of glycerophospholipids

Subclass Name Activity Medical application Ref.
PC PC Lipolysis in human fat tissue Cosmetic procedure Thomas et al., 2016
Lipolysis in malar, jawline, submental areas and upper arm Cosmetic procedure Thomas et al., 2018
Promote adipocyte-specific lipolysis and apoptosis through TNF-α or IL-1β signaling Adipocyte lipolysis and apoptosis Jung et al., 2019
Reduce gastric bleeding, prevent GI permeability disturbance due to LPS Gastrointestinal tract inflammation Dial et al., 2008
Improves intestinal barrier function. Drug-induced Liver injury Chen et al., 2019
Polyenylphosphatidylcholine Protective effects against lipid peroxidation, oxidative stress and hepatic fibrosis Fatty liver, metabolic comorbidities Maev et al., 2020
PI Phosphatidylinositol (3, 4, 5) – trisphosphate
(PI(3,4,5)P3)
Signaling molecule processed by phosphatidylinositol 3-kinase Insulin resistance Kachko et al., 2015
PS PS Suppress the TNF-α production of peritoneal macrophage Inflammatory disease Klein et al., 2020
Interfere with the pro-inflammatory cytokine formation of phagocyte Inflammatory disease Szondy et al., 2017
Lecithin-transphosphatidylated PS Restored age-associated decreases of choline transporter Memory impairment Lee et al., 2015
Plasmalogen Ethanolamine plasmalogen Correlation of declined circulating plasmalogen and cognitive function Alzheimer’s disease Wood et al., 2010
Enhanced inhibition activity of phosphatidylethanolamine on γ-secretase Alzheimer’s disease Onodera et al., 2015
Improvement of cognitive functions Alzheimer’s disease Fujino et al., 2017
Improved memory impairment in amyloid β-infused rats Alzheimer’s disease Yamashita et al., 2017
Biomolecules & Therapeutics 2021;29:465~482 https://doi.org/10.4062/biomolther.2021.107
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