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Fig. 5. Attenuation of DSS-induced colitis by the novel GPR43 agonists. Colitis was induced as described in Materials and Methods. The phenotypes were examined every day. Daily activity index (E) was calculated by summation of clinical scores for body weight (A, B), rectal bleeding (C) and stool consistency (D). On day 8, the entire colon was excised and colon length measured (F). The excised colon was subject to MPO staining (G). The representative samples from three mice were shown. n=5 in Control and n=10 in other groups. Data are expressed as means ± SEM from three independent experiments with Student’s t-test. *p<0.05, ***p<0.005 were considered significant.
Biomolecules & Therapeutics 2022;30:48~54 https://doi.org/10.4062/biomolther.2021.078
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