Fig. 4. Inhibition of NFκB activity by activated GPR43. (A) Concentration responses of the indicated agonists in downregulation of NF-κB activity induced by 10 ng/mL TNF-α from GPR43-expressing cells. (B) Reduced IκBα via stimulation of TNF-α was rescued by treatment with agonists for GPR43. (C) Quantification of total IκBα: β-actin ratio analyzed using Image J software. Data are expressed as means ± SEM from three independent experiments with Student’s t-test. p values <0.05 were considered significant.
© Biomolecules & Therapeutics
