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Fig. 3. Novel agonists for GPR43 with allosterism. Various fixed concentrations of acetate were added to Ca2+ and Nano Live Glo assay to examine interactions between GPR43 and β-arrestin 2 for (A, B) PAAT, (C, D) compound 110, and (E, F) compound 187. GPR43-expressing HEK293 cells were simultaneously treated with acetate and the indicated agonists.
Biomolecules & Therapeutics 2022;30:48~54 https://doi.org/10.4062/biomolther.2021.078
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