Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

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Fig. 6. Possible STAT3 signal transduction pathways in SARS-CoV-2-infected Vero Cells and Calu-3 cells. SARS-CoV-2 enters host cells by binding to the cell surface receptor ACE2. Cellular responses to SARS-CoV-2 differ depending on the host cell type. In Vero cells, STAT1 and STAT3 are dephosphorylated within 2 days after virus infection and apoptosis occurs as observed by an increase in the amount of cleaved PARP and cleaved Caspase-3. In contrast, in Calu-3 cells, phosphorylation of STAT1 and STAT3 persists for days after virus infection and no prominent apoptosis occurs, but induction of proliferation-associated Cyclin D1 and c-Myc proteins occurs. Phosphorylation and dimerization of STAT3 are required for virus production in Calu-3 cells. Possible regulation of the STAT3 signaling pathways by SARS-CoV-2 proteins is shown.
Biomolecules & Therapeutics 2021;29:273~281
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