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Fig. 1. CYM50358 represses antigen-induced degranulation in RBL-2H3 mast cells. After sensitization with anti-DNP IgE for 18 h, RBL-2H3 cells were challenged with DNP human serum albumin (HSA). CYM50358 was treated at the indicated concentrations 30 min before antigen challenge. Basal degranulation shows samples without IgE and HSA, and the positive control of antigen-induced degranulation is shown in the samples with IgE and HSA. The results are presented as the means ± standard error (SE) of three independent experiments. ***p<0.001 vs. the HSA-untreated group. ###p<0.001 vs. the HSA-treated group.
Biomolecules & Therapeutics 2021;29:492~497 https://doi.org/10.4062/biomolther.2020.206
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