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Fig. 6. Regulation of MMP-1 in dermal fibroblast by supernatant derived from keratinocytes. HaCaT was pre-treated with different concentrations of oleanolic acid (2.5, 5, 10 μg/mL) for 24 h, and co-treated with oleanolic acid and PM10 (100 μg/mL) for 30 min. After treatment, fresh media were changed and incubated for 24 h. HDFs were treated with the supernatant derived from HaCaT for 30 min. After treatment, fresh media were changed and incubated for 48 h. Supernatants derived from HDFs were used to analyze Enzyme linked immunosorbent assay (ELISA). Values are presented as the mean ± SD of three determinations (n=3). The MMP-1 level of control was 93 ng/mL. **p<0.01 versus PM10 treatment group; ##p<0.01 versus control group.
Biomolecules & Therapeutics 2021;29:220~226 https://doi.org/10.4062/biomolther.2020.106
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