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Fig. 5. Resorcinol-induced activation of the Nrf2/HO-1 pathway is not mediated by AhR. (A, B) HaCaT cells were transiently transfected with control siRNA, AhR siRNA, or NrF2 siRNA using the DharmaFECT® Duo transfection reagent (Thermo Fischer Scientific, Waltham, MA, USA). After incubation for 24 h, the cells were treated with resorcinol (3 mM) in the presence of B[a]P for 24 h. The cells were then subjected to real-time PCR analysis for HO-1 and CYP1A1. *p<0.05 vs. resorcinol-treated control (A). *p<0.05 vs. B[a]P-treated control (B). *p<0.05 vs. (B[a]P+resorcinol)-treated control. Three biological experimental replicates were performed. Data are presented as mean ± SD. RES, resorcinol.
Biomolecules & Therapeutics 2021;29:227~233
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