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Fig. 5. Dasatinib inhibits IgE-mediated passive cutaneous anaphylaxis. DNP-specific IgE was intradermally injected into the mice’s ears. After 24 h, dasatinib or cetirizine in 5% Arabic gum were orally administrated to the mice 1 h before the tail vein injection of 250 µL of Evans blue with or without antigen. After that, mice were euthanized and ears were removed for the extraction of Evans blue dye in formamide. (A) Representative ear images are shown from three independent experiments. (B) Data for the amount of Evans blue dye are expressed as the mean ± SEM of values obtained from three independent experiments (n≥15). (C) The representative images for resting or degranulated ear tissue MC (insets) and the percentage of degranulated MCs per total MCs were presented. Data are expressed as the mean ± SEM of values obtained from three independent experiments (n≥15). Significance differences against the antigen-stimulated group without dasatinib or cetirizine are indicated. *p<0.05 and **p<0.01.
Biomolecules & Therapeutics 2020;28:456~464 https://doi.org/10.4062/biomolther.2020.013
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