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Fig. 2. LC-MS/MS analysis of diclofenac hydroxylation by P450 2C9. (A) Chromatogram and fragmentation of diclofenac in the multiple reaction mode (MRM), (B) Chromatogram and fragmentation of 4-hydroxydiclofenac in the MRM. The transitions of the 4-hydroxydiclofenac-H+ adduct (m/z 314.15>231.15) and the diclofenac-H+ adduct (m/z 296>214) were monitored.
Biomolecules & Therapeutics 2019;27:577~583
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