Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Cited by CrossRef (183)

  1. M. Lylyk, O. Sorochynska, O. Maniukh, M. Bayliak. Gender differences of amino acid metabolism in Drosophila melanogaster on alpha-ketoglutarate-supplemented food. BTSNUKSPPFR 2016;21:31
    https://doi.org/10.17721/2616_6410.2016.21.31-36
  2. Ziwei Han, Bolaji F. Oyeyemi, Jenny E. Zenobio, Omobayo A. Salawu, Adeyemi S. Adeleye. Perfluorooctanoic acid dominates the molecular-level effects of a mixture of equal masses of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm. Journal of Hazardous Materials 2023;457:131718
    https://doi.org/10.1016/j.jhazmat.2023.131718
  3. Sadia Naz, Pi Liu, Umar Farooq, Hongwu Ma. Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method. Microb Cell Fact 2023;22
    https://doi.org/10.1186/s12934-023-02178-z
  4. G. Morris, K. R. Walder, M. Berk, W. Marx, A. J. Walker, M. Maes, B. K. Puri. The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?. Mol Biol Rep 2020;47:5587
    https://doi.org/10.1007/s11033-020-05590-5
  5. Phaneendra Batchu, Aditya Naldurtiker, Brou Kouakou, Thomas H. Terrill, George W. McCommon, Govind Kannan. Metabolomic exploration of the effects of habituation to livestock trailer and extended transportation in goats. Front. Mol. Biosci. 2022;9
    https://doi.org/10.3389/fmolb.2022.1027069
  6. Laetitia Gibart, Rajeev Khoodeeram, Gilles Bernot, Jean-Paul Comet, Jean-Yves Trosset. Regulation of Eukaryote Metabolism: An Abstract Model Explaining the Warburg/Crabtree Effect. Processes 2021;9:1496
    https://doi.org/10.3390/pr9091496
  7. Bibek Gyanwali, Zi Xiang Lim, Janjira Soh, Clarissa Lim, Shou Ping Guan, Jorming Goh, Andrea B. Maier, Brian K. Kennedy. Alpha-Ketoglutarate dietary supplementation to improve health in humans. Trends in Endocrinology & Metabolism 2022;33:136
    https://doi.org/10.1016/j.tem.2021.11.003
  8. Andre Catic. Metabolic Aspects of Aging. 2022.
    https://doi.org/10.1016/bs.pmbts.2017.12.003
  9. P. Mara, G. S. Fragiadakis, F. Gkountromichos, D. Alexandraki. The pleiotropic effects of the glutamate dehydrogenase (GDH) pathway in Saccharomyces cerevisiae. Microb Cell Fact 2018;17
    https://doi.org/10.1186/s12934-018-1018-4
  10. Anders Bagger Sørensen, Jesper Harholt, Nils Arneborg. Application of Yarrowia lipolytica in fermented beverages. Front. Food. Sci. Technol. 2023;3
    https://doi.org/10.3389/frfst.2023.1190063
  11. Laura F. Grogan, Lee F. Skerratt, Lee Berger, Scott D. Cashins, Robert D. Trengove, Joel P. A. Gummer. Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathways. Sci Rep 2018;8
    https://doi.org/10.1038/s41598-018-26427-z
  12. Qian Jiang, Liuqin He, Yongqing Hou, Jiashun Chen, Yehui Duan, Dun Deng, Guoyao Wu, Yulong Yin, Kang Yao. Alpha-ketoglutarate enhances milk protein synthesis by porcine mammary epithelial cells. Amino Acids 2016;48:2179
    https://doi.org/10.1007/s00726-016-2249-5
  13. Alfred B. Ordman. When Will the FDA Do What Is in People’s Best Interests?. American J Econ Sociol 2022;81:721
    https://doi.org/10.1111/ajes.12481
  14. Sabine Mann, Joshua D. Ramsay, Joseph J. Wakshlag, Tracy Stokol, Steven Reed, Thomas J. Divers. Investigating the pathogenesis of high‐serum gamma‐glutamyl transferase activity in Thoroughbred racehorses: A series of case‐control studies. Equine Veterinary Journal 2022;54:39
    https://doi.org/10.1111/evj.13435
  15. Udit Gupta, Tung Le, Wei-Shou Hu, Aditya Bhan, Prodromos Daoutidis. Automated network generation and analysis of biochemical reaction pathways using RING. Metabolic Engineering 2018;49:84
    https://doi.org/10.1016/j.ymben.2018.07.009
  16. Tomasz Niemiec, Klara Zglińska, Wiesław Świderek, Weronika Górecka, Magdalena Matusiewicz, Andrzej Łozicki, Iwona Kosieradzka, Stefan Pierzynowski. The effect of alpha-ketoglutarate (AKG) on the behaviour of ageing laboratory mice. 2018;14:31
    https://doi.org/10.5604/01.3001.0013.5081
  17. Fan Wu, Xuexia Xie, Guoliang Li, Dongping Bao, Haomin Li, Guohao Wu, Yiqi Lai, Yaping Xing, Peng Ouyang, Guo Chen, Zhifeng Wang, Caiyong Lai. AKG induces cell apoptosis by inducing reactive oxygen species‐mediated endoplasmic reticulum stress and by suppressing PI3K/AKT/mTOR‐mediated autophagy in renal cell carcinoma. Environmental Toxicology 2023;38:17
    https://doi.org/10.1002/tox.23658
  18. Gokulnath Samaegounder Ramakrishnan, Chiranjiv Pradhan, Anil Kumar Singh, Sweta Das, Devika Pillai, Kedar Nath Mohanta. Effect of alpha-ketoglutarate supplementation on growth, antioxidant capacity, gene expression and amino acid profile in Nile tilapia (Oreochromis niloticus) under varying protein diets. Animal Feed Science and Technology 2023;306:115808
    https://doi.org/10.1016/j.anifeedsci.2023.115808
  19. Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H. Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn. Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis. Nat Commun 2020;11
    https://doi.org/10.1038/s41467-020-19959-4
  20. Eduardo Izquierdo-Torres, Andrés Hernández-Oliveras, Dalia Lozano-Arriaga, Ángel Zarain-Herzberg. Obesity, the other pandemic: linking diet and carcinogenesis by epigenetic mechanisms. The Journal of Nutritional Biochemistry 2022;108:109092
    https://doi.org/10.1016/j.jnutbio.2022.109092
  21. Oleksandr Demidenko, Diogo Barardo, Valery Budovskii, Robb Finnemore, Francis R. Palmer, Brian K. Kennedy, Yelena V. Budovskaya. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging 2021;13:24485
    https://doi.org/10.18632/aging.203736
  22. Okon Dominic Ekpe, Gyojin Choo, Younghun Choi, Junho Jeon, Jeong-Eun Oh. Long-term degradation of toluene and phenol in soil: Identification of transformation products and pathways via HRMS-based suspect and non-target screening. Journal of Hazardous Materials 2022;430:128429
    https://doi.org/10.1016/j.jhazmat.2022.128429
  23. Elisabet Foguet-Romero, Iris Samarra, Maria Guirro, Marc Riu, Jorge Joven, Javier A. Menendez, Núria Canela, Antoni DelPino-Rius, Salvador Fernández-Arroyo, Pol Herrero. Optimization of a GC-MS Injection-Port Derivatization Methodology to Enhance Metabolomics Analysis Throughput in Biological Samples. J. Proteome Res. 2022;21:2555
    https://doi.org/10.1021/acs.jproteome.2c00119
  24. Zhengtao Liu, Junsheng Zhao, Wenchao Wang, Hai Zhu, Junjie Qian, Shuai Wang, Shuping Que, Feng Zhang, Shengyong Yin, Lin Zhou, Lei Geng, Shusen Zheng, Xianquan Zhan. Integrative Network Analysis Revealed Genetic Impact of Pyruvate Kinase L/R on Hepatocyte Proliferation and Graft Survival after Liver Transplantation. Oxidative Medicine and Cellular Longevity 2021;2021:1
    https://doi.org/10.1155/2021/7182914
  25. Vaishali Gupta, Chris Major Ncho, Akshat Goel, Chae-Mi Jeong, Yang-Ho Choi. Effects of In Ovo Injection of α-Ketoglutaric Acid on Hatchability, Growth, Plasma Metabolites, and Antioxidant Status of Broilers. Antioxidants 2022;11:2102
    https://doi.org/10.3390/antiox11112102
  26. Rishi Sharma, Arvind Ramanathan. The Aging Metabolome—Biomarkers to Hub Metabolites. Proteomics 2020;20
    https://doi.org/10.1002/pmic.201800407
  27. Xue Zhang, Ning Xu, Jialong Li, Zhenping Ma, Liang Wei, Qingdai Liu, Jun Liu. Engineering of L-glutamate oxidase as the whole-cell biocatalyst for the improvement of α-ketoglutarate production. Enzyme and Microbial Technology 2020;136:109530
    https://doi.org/10.1016/j.enzmictec.2020.109530
  28. Matteo Antoine Negroni, Francisca H. I. D. Segers, Fanny Vogelweith, Susanne Foitzik. Immune challenge reduces gut microbial diversity and triggers fertility-dependent gene expression changes in a social insect. BMC Genomics 2020;21
    https://doi.org/10.1186/s12864-020-07191-9
  29. Sahil Inamdar, Tina Tylek, Abhirami Thumsi, Abhirami P. Suresh, Madhan Mohan Chandra Sekhar Jaggarapu, Michelle Halim, Shivani Mantri, Arezoo Esrafili, Nathan D. Ng, Elizabeth Schmitzer, Kelly Lintecum, Camila de Ávila, John D. Fryer, Ying Xu, Kara L. Spiller, Abhinav P. Acharya. Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models. Biomaterials 2023;293:121973
    https://doi.org/10.1016/j.biomaterials.2022.121973
  30. William Errickson, Bingru Huang. Rhizobacteria‐enhanced drought tolerance and post‐drought recovery of creeping bentgrass involving differential modulation of leaf and root metabolism. Physiologia Plantarum 2023;175
    https://doi.org/10.1111/ppl.14004
  31. Suhail Razak, Tayyaba Afsar, Dara Al-Disi, Ali Almajwal, Mohammed Arshad, Abdullah A. Alyousef, Rukaya Amin Chowdary. GCMS fingerprinting, in vitro pharmacological activities, and in vivo anti-inflammatory and hepatoprotective effect of selected edible herbs from Kashmir valley. Journal of King Saud University - Science 2020;32:2868
    https://doi.org/10.1016/j.jksus.2020.07.011
  32. X. Wang, H. Wang, H. Wu. Dietary and ergogenic supplementation to improve elite swimming players’ performance and recovery. Science & Sports 2023;38:510
    https://doi.org/10.1016/j.scispo.2022.12.004
  33. Katherine J. Wert, Gabriel Velez, Vijaya L. Kanchustambham, Vishnu Shankar, Lucy P. Evans, Jesse D. Sengillo, Richard N. Zare, Alexander G. Bassuk, Stephen H. Tsang, Vinit B. Mahajan. Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration. EBioMedicine 2020;52:102636
    https://doi.org/10.1016/j.ebiom.2020.102636
  34. Alexandros Grivas, George Fragoulis, Panagiotis Garantziotis, Aggelos Banos, Elena Nikiphorou, Dimitrios Boumpas. Unraveling the complexities of psoriatic arthritis by the use of -Omics and their relevance for clinical care. Autoimmunity Reviews 2021;20:102949
    https://doi.org/10.1016/j.autrev.2021.102949
  35. José Jesús Broseta, Marta Roca, Diana Rodríguez-Espinosa, Luis Carlos López-Romero, Aina Gómez-Bori, Elena Cuadrado-Payán, Ramón Devesa-Such, Amparo Soldevila, Sergio Bea-Granell, Pilar Sánchez-Pérez, Julio Hernández-Jaras. Impact of Acetate versus Citrate Dialysates on Intermediary Metabolism—A Targeted Metabolomics Approach. IJMS 2022;23:11693
    https://doi.org/10.3390/ijms231911693
  36. Wei Liu, Yaoting Sun, Weigang Ge, Fangfei Zhang, Lin Gan, Yi Zhu, Tiannan Guo, Kexin Liu. DIA-Based Proteomics Identifies IDH2 as a Targetable Regulator of Acquired Drug Resistance in Chronic Myeloid Leukemia. Molecular & Cellular Proteomics 2022;21:100187
    https://doi.org/10.1016/j.mcpro.2021.100187
  37. Diego Camuzi, Ísis de Amorim, Luis Ribeiro Pinto, Leonardo Oliveira Trivilin, André Mencalha, Sheila Soares Lima. Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer. Cells 2019;8:300
    https://doi.org/10.3390/cells8040300
  38. Jie Zhao, Cen Xie, Xiyan Mu, Kristopher W. Krausz, Daxesh P. Patel, Xiaowei Shi, Xiaoxia Gao, Qiao Wang, Frank J. Gonzalez. Metabolic alterations in triptolide‐induced acute hepatotoxicity. Biomedical Chromatography 2018;32
    https://doi.org/10.1002/bmc.4299
  39. Mengyao Shi, Jiang He, Changwei Li, Xiangfeng Lu, William J. He, Jie Cao, Jing Chen, Ji-Chun Chen, Lydia A. Bazzano, Jian-Xin Li, Hua He, Dongfeng Gu, Tanika N. Kelly. Metabolomics study of blood pressure salt-sensitivity and hypertension. Nutrition, Metabolism and Cardiovascular Diseases 2022;32:1681
    https://doi.org/10.1016/j.numecd.2022.04.002
  40. I. V. Kukes, V. G. Lim, K. A. Ivantsov, E. Yu. Solovyeva, L. P. Sokolova, I. R. Gilmutdinova, P. B. Glagovskiy, M. S. Ptitsyn. Possibilities of personalized pharmacotherapy and medical rehabilitation of patients with long COVID from the perspective of clinical metabolomics. Medicinskij sovet 2023:57
    https://doi.org/10.21518/ms2023-111
  41. Daniel G Tenen, Li Chai, Justin L Tan. Metabolic alterations and vulnerabilities in hepatocellular carcinoma. 2021;9:1
    https://doi.org/10.1093/gastro/goaa066
  42. Olha Kostiuchenko, Iryna Lushnikova, Magdalena Kowalczyk, Galyna Skibo. mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection. BBA Advances 2022;2:100066
    https://doi.org/10.1016/j.bbadva.2022.100066
  43. Cedric Wüthrich, Miguel de Figueiredo, Kathryn Jane Burton-Pimentel, Guy Vergères, Fabian Wahl, Renato Zenobi, Stamatios Giannoukos. Breath response following a nutritional challenge monitored by secondary electrospray ionization high-resolution mass spectrometry. J. Breath Res. 2022;16:046007
    https://doi.org/10.1088/1752-7163/ac894e
  44. Piotr Dobrowolski, Ewa Tomaszewska, Siemowit Muszyński, Tomasz Blicharski, Stefan G Pierzynowski. Dietary 2-oxoglutarate prevents bone loss caused by neonatal treatment with maximal dexamethasone dose. Exp Biol Med (Maywood) 2017;242:671
    https://doi.org/10.1177/1535370217693322
  45. Yanfeng Liu, Long Liu. Systems and Synthetic Biotechnology for Production of Nutraceuticals. 2017.
    https://doi.org/10.1007/978-981-15-0446-4_1
  46. Rishi Rajesh, Reham Atallah, Thomas Bärnthaler. Dysregulation of metabolic pathways in pulmonary fibrosis. Pharmacology & Therapeutics 2023;246:108436
    https://doi.org/10.1016/j.pharmthera.2023.108436
  47. Hailang He, Tingyu Pan, Xiaojian Shi, Shuang Yang, Paniz Jasbi, Yan Jin, Julia Yue Cui, Haiwei Gu. An integrative cellular metabolomic study reveals downregulated tricarboxylic acid cycle and potential biomarkers induced by tetrabromobisphenol A in human lung A549 cells. Environmental Toxicology 2023;38:7
    https://doi.org/10.1002/tox.23657
  48. Juliana Camacho-Pereira, Leonardo Osbourne Lai de Souza, Marina Santos Chichierchio, Camila Rodrigues-Chaves, Luiza de Sousa Lomba, Manoel Fonseca-Oliveira, Daniel Carvalho-Mendonça, Thaia Silva-Rodrigues, Antonio Galina. The NADase CD38 may not dictate NAD levels in brain mitochondria of aged mice but regulates hydrogen peroxide generation. Free Radical Biology and Medicine 2023;209:29
    https://doi.org/10.1016/j.freeradbiomed.2023.09.035
  49. Di Wu, Ze Fan, Jinnan Li, Yuanyuan Zhang, Qiyou Xu, Liang Wang, Liansheng Wang. Low Protein Diets Supplemented With Alpha-Ketoglutarate Enhance the Growth Performance, Immune Response, and Intestinal Health in Common Carp (Cyprinus carpio). Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.915657
  50. Ulf Kulik, Caroline Moesta, Reinhard Spanel, Jürgen Borlak. Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary nonfunction of fatty liver allografts. Translational Research 2023
    https://doi.org/10.1016/j.trsl.2023.09.006
  51. Richard X. Liu, Neel Koyawala, Heather R. Thiessen-Philbrook, Mona D. Doshi, Peter P. Reese, Isaac E. Hall, Sumit Mohan, Chirag R. Parikh. Untargeted metabolomics of perfusate and their association with hypothermic machine perfusion and allograft failure. Kidney International 2023;103:762
    https://doi.org/10.1016/j.kint.2022.11.020
  52. Ni Lian, Li-Qing Shi, Zhi-Min Hao, Min Chen. Research progress and perspective in metabolism and metabolomics of psoriasis. 2020;133:2976
    https://doi.org/10.1097/CM9.0000000000001242
  53. Ewa Tomaszewska, Sylwester Świątkiewicz, Anna Arczewska-Włosek, Dorota Wojtysiak, Piotr Dobrowolski, Piotr Domaradzki, Izabela Świetlicka, Janine Donaldson, Monika Hułas-Stasiak, Siemowit Muszyński. Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study. Animals 2020;10:2420
    https://doi.org/10.3390/ani10122420
  54. Ewa Tomaszewska, Anna Arczewska-Włosek, Artur Burmańczuk, Renata Pyz-Łukasik, Janine Donaldson, Siemowit Muszyński, Sylwester Świątkiewicz. The Effect of L-Glutamine on Basal Albumen and Yolk Indices, and Albumen Amino Acids Composition. Animals 2021;11:3556
    https://doi.org/10.3390/ani11123556
  55. Shuhan Lei, Bingru Huang. Metabolic regulation of α-Ketoglutarate associated with heat tolerance in perennial ryegrass. Plant Physiology and Biochemistry 2022;190:164
    https://doi.org/10.1016/j.plaphy.2022.09.005
  56. Yan Han, Xingping Quan, Yaochen Chuang, Qiaoxing Liang, Yang Li, Zhen Yuan, Ying Bian, Lai Wei, Ji Wang, Yonghua Zhao. A multi‐omics analysis for the prediction of neurocognitive disorders risk among the elderly in Macao. Clinical & Translational Med 2022;12
    https://doi.org/10.1002/ctm2.909
  57. Lidan Hu, Li Lin, Guoping Huang, Yi Xie, Zhaoyang Peng, Fei Liu, Guannan Bai, Wei Li, Langping Gao, Yan Wang, Qiuyu Li, Haidong Fu, Jingjing Wang, Qingnan Sun, Jianhua Mao. Metabolomic profiles in serum and urine uncover novel biomarkers in children with nephrotic syndrome. Eur J Clin Investigation 2023;53
    https://doi.org/10.1111/eci.13978
  58. Chaitra Surugihalli, Tom E. Porter, Angela Chan, Linda S. Farley, Meghan Maguire, Christine Zhang, Nathan Kattapuram, Muhammed S. Muyyarikkandy, Hsiao-Ching Liu, Nishanth E. Sunny. Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-56715-1
  59. Elise Malard, Samuel Valable, Myriam Bernaudin, Elodie Pérès, Laurent Chatre. The Reactive Species Interactome in the Brain. Antioxidants & Redox Signaling 2021;35:1176
    https://doi.org/10.1089/ars.2020.8238
  60. Renata Wawrzyniak, Peter Grešner, Ewa Lewicka, Szymon Macioszek, Artur Furga, Bożena Zieba, Michał J. Markuszewski, Alicja Da̧browska-Kugacka. Metabolomics Meets Clinics: A Multivariate Analysis of Plasma and Urine Metabolic Signatures in Pulmonary Arterial Hypertension. J. Proteome Res. 2023
    https://doi.org/10.1021/acs.jproteome.3c00255
  61. Yuling Ma, Sumei Zhou, Jing Lu. Metabolomic Analysis Reveals Changes of Bioactive Compounds in Mung Beans (Vigna radiata) during γ-Aminobutyric Acid Enrichment Treatment. Foods 2022;11:1423
    https://doi.org/10.3390/foods11101423
  62. Weichuan Xiong, Alexander Perna, Ikechukwu B. Jacob, Benjamin R. Lundgren, Guirong Wang, Igor E. Brodsky. The Enhancer-Binding Protein MifR, an Essential Regulator of α-Ketoglutarate Transport, Is Required for Full Virulence of Pseudomonas aeruginosa PAO1 in a Mouse Model of Pneumonia. Infect Immun 2022;90
    https://doi.org/10.1128/iai.00136-22
  63. Natsuko Miura, Chandrasekhar Mushti, Deepak Sail, Jenna E. AbuSalim, Kazutoshi Yamamoto, Jeffrey R. Brender, Tomohiro Seki, Deyaa I. AbuSalim, Shingo Matsumoto, Kevin A. Camphausen, Murali C. Krishna, Rolf E. Swenson, Aparna H. Kesarwala. Synthesis of [1‐13C‐5‐12C]‐alpha‐ketoglutarate enables noninvasive detection of 2‐hydroxyglutarate. NMR in Biomedicine 2021;34
    https://doi.org/10.1002/nbm.4588
  64. Cindy Mendes, Isabel Lemos, Inês Francisco, Teresa Almodôvar, Fernando Cunha, Cristina Albuquerque, Luís G. Gonçalves, Jacinta Serpa. NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF stimuli in EGFR-mutated NSCLC. Lung Cancer 2023;182:107283
    https://doi.org/10.1016/j.lungcan.2023.107283
  65. Ewa Tomaszewska, Siemowit Muszyński, Anna Arczewska-Włosek, Piotr Domaradzki, Renata Pyz-Łukasik, Janine Donaldson, Sylwester Świątkiewicz. Cholesterol Content, Fatty Acid Profile and Health Lipid Indices in the Egg Yolk of Eggs from Hens at the End of the Laying Cycle, Following Alpha-Ketoglutarate Supplementation. Foods 2021;10:596
    https://doi.org/10.3390/foods10030596
  66. Sofiya Gancheva, Tomas Jelenik, Elisa Álvarez-Hernández, Michael Roden. Interorgan Metabolic Crosstalk in Human Insulin Resistance. Physiological Reviews 2018;98:1371
    https://doi.org/10.1152/physrev.00015.2017
  67. Laura F. Grogan, Josephine E. Humphries, Jacques Robert, Chantal M. Lanctôt, Catherine J. Nock, David A. Newell, Hamish I. McCallum. Immunological Aspects of Chytridiomycosis. JoF 2020;6:234
    https://doi.org/10.3390/jof6040234
  68. Abubakar Sha’aban, Hadzliana Zainal, Nor Azlina Khalil, Fatimatuzzahra’ Abd Aziz, Ewe Seng Ch’ng, Chin-Hoe Teh, Mustapha Mohammed, Baharudin Ibrahim. Prediction of Low-Dose Aspirin-Induced Gastric Toxicity Using Nuclear Magnetic Resonance Spectroscopy-Based Pharmacometabolomics in Rats. Molecules 2022;27:2126
    https://doi.org/10.3390/molecules27072126
  69. Zhen Cheng, Yaqin Peng, Jun Wen, Wenwen Chen, Weichao Pan, Xing Xu, Xue Lu, Qinglong Cai, Feifei Ge, Yu Fan, Jun Wang, Xiaowei Guan. Sex‐specific metabolic signatures in methamphetamine addicts. Addiction Biology 2023;28
    https://doi.org/10.1111/adb.13255
  70. Tianlong Li, Jie Liu, Ke Liu, Qian Wang, Junna Cao, Ping Xiao, Wenqin Yang, Xiang Li, Jiangming Li, Meng Li, Xuehan Tang, Meixiang Li, Shun Zhang, Xiaocan Lei. Alpha-ketoglutarate ameliorates induced premature ovarian insufficiency in rats by inhibiting apoptosis and upregulating glycolysis. Reproductive BioMedicine Online 2023;46:673
    https://doi.org/10.1016/j.rbmo.2023.01.005
  71. Haruko Nakano, Atsushi Nakano. Heart Development and Disease. 2023.
    https://doi.org/10.1016/bs.ctdb.2024.01.005
  72. Jifei Wang, Zhaoying Li, Guang Yang, Chao Fang, Yanwei Yin, Zhilei Zheng, Hongwei Wang, Shaohong Fang, Jiannan Dai, Shanjie Wang, Shuang Yang, Bo Yu. Pseudo-targeted metabolic profile differences between emergency patients with type 1 and type 2 myocardial infarction diagnosed by optical coherence tomography. Clinica Chimica Acta 2024;554:117745
    https://doi.org/10.1016/j.cca.2023.117745
  73. Isabella Corsato Alvarenga, Charles Aldrich, Dennis Jewell. Influence of Liver Condition and Copper on Selective Parameters of Post-Mortem Dog Tissue Samples. Animals 2018;8:237
    https://doi.org/10.3390/ani8120237
  74. L. Bervoets, P. Adriaensens. Nutritional Signaling Pathway Activities in Obesity and Diabetes. 2018.
    https://doi.org/10.1039/9781839160608-00210
  75. F. Legendre, A. MacLean, V. P. Appanna, V. D. Appanna. Biochemical pathways to α-ketoglutarate, a multi-faceted metabolite. World J Microbiol Biotechnol 2020;36
    https://doi.org/10.1007/s11274-020-02900-8
  76. Elena Sandalova, Jorming Goh, Zi Xiang Lim, Zhi Meng Lim, Diogo Barardo, Rajkumar Dorajoo, Brian K. Kennedy, Andrea B. Maier. Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol. GeroScience 2023;45:2897
    https://doi.org/10.1007/s11357-023-00813-6
  77. Xiaoning Liu, Liangdan Wu, Yujia Si, Yujie Zhai, Mingyi Niu, Mei Han, Tao Su. Regulating Effect of Exogenous α-Ketoglutarate on Ammonium Assimilation in Poplar. Molecules 2024;29:1425
    https://doi.org/10.3390/molecules29071425
  78. Silvia Piccirillo, Simona Magi, Pasqualina Castaldo, Alessandra Preziuso, Vincenzo Lariccia, Salvatore Amoroso. NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival. Cell Calcium 2020;86:102160
    https://doi.org/10.1016/j.ceca.2020.102160
  79. Xiao Wang, Haja N. Kadarmideen. Metabolomics Analyses in High-Low Feed Efficient Dairy Cows Reveal Novel Biochemical Mechanisms and Predictive Biomarkers. Metabolites 2019;9:151
    https://doi.org/10.3390/metabo9070151
  80. Lijing Guo, Shihua Chen, Liping Ou, Shangmei Li, Zhen-Nan Ye, Hua-Feng Liu. Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond. DMSO 2022;Volume 15:1961
    https://doi.org/10.2147/DMSO.S369090
  81. Lakshminarayanan Gowtham, Nabanita Halder, Dewang Angmo, Sundararajan Baskar Singh, Rama Jayasundar, Tanuj Dada, Thirumurthy Velpandian. Untargeted metabolomics in the aqueous humor reveals the involvement of TAAR pathway in glaucoma. Experimental Eye Research 2023;234:109592
    https://doi.org/10.1016/j.exer.2023.109592
  82. Ruixia Lu, Wenyong Lin, Qipeng Jin, Dongyuan Wang, Chunling Zhang, Huiying Wang, Tiejun Chen, Junjie Gao, Xiaolong Wang. Plasma Metabolic Profiling and Multiclass Diagnostic Model Development for Stable Angina Pectoris and Acute Myocardial Infarction. ACS Omega 2024;9:16322
    https://doi.org/10.1021/acsomega.3c10474
  83. Pengfei Cui, Caihua Huang, Jiaqi Guo, Qianwen Wang, Zhiqing Liu, Huiqin Zhuo, Donghai Lin. Metabolic Profiling of Tumors, Sera, and Skeletal Muscles from an Orthotopic Murine Model of Gastric Cancer Associated-Cachexia. J. Proteome Res. 2019;18:1880
    https://doi.org/10.1021/acs.jproteome.9b00088
  84. Lige Xiao, Guanteng Yang, Hongqi Zhang, Jinyang Liu, Chaofeng Guo, Yang Sun, Shuai Chen. Nontargeted Metabolomic Analysis of Plasma Metabolite Changes in Patients with Adolescent Idiopathic Scoliosis. Mediators of Inflammation 2021;2021:1
    https://doi.org/10.1155/2021/5537811
  85. Yiming Li, Huixin Yang, Bin Yu, Jiayao Wang, Manli Zhu, Jiao Liu, Zhenjie Zheng, Zhenning Qian, Linya Wei, Huanyong Lv, Lili Zhang, Yunhe Xu. Fermentation improves flavors, bioactive substances, and antioxidant capacity of Bian-Que Triple-Bean Soup by lactic acid bacteria. Front. Microbiol. 2023;14
    https://doi.org/10.3389/fmicb.2023.1152654
  86. Pedro Caetano-Pinto, Simone H. Stahl. Renal Organic Anion Transporters 1 and 3 In Vitro: Gone but Not Forgotten. IJMS 2023;24:15419
    https://doi.org/10.3390/ijms242015419
  87. Mingyan Hou, Kai Zheng, Fenghong Chu, Youhua Jiang, Chuankai Yang, Chao Jiang, Liang Xue. Molecular Study on Conformational Changes in Trypsin Inhibitors in Multidirectional Electrostatic Fields. Applied Sciences 2024;14:1213
    https://doi.org/10.3390/app14031213
  88. Saud Alamri, Qasi D. Alsubaie, Abdullah A. Al‐Amri, Bandar Al‐Munqedi, Hayssam M. Ali, Bishwajit K. Kushwaha, Vijay P. Singh, Manzer H. Siddiqui. Priming of tomato seedlings with 2‐oxoglutarate induces arsenic toxicity alleviatory responses by involving endogenous nitric oxide. Physiol Plantarum 2020
    https://doi.org/10.1111/ppl.13168
  89. Wei-Lin Tu, Chuen-Yu Cheng, Chao-Jung Chen, Hong-Lin Chan, Shih-Han Wang, Pin-Chi Tang, Chih-Feng Chen, Yen-Pai Lee, Shuen-Ei Chen, San-Yuan Huang. Annotation of differential protein expression in the hypothalami of layer-type Taiwan country chickens in response to acute heat stress. Journal of Thermal Biology 2018;77:157
    https://doi.org/10.1016/j.jtherbio.2018.08.013
  90. Julia Hernandez-Baixauli, Pere Puigbò, Nerea Abasolo, Hector Palacios-Jordan, Elisabet Foguet-Romero, David Suñol, Mar Galofré, Antoni Caimari, Laura Baselga-Escudero, Josep M. Del Bas, Miquel Mulero. Alterations in Metabolome and Microbiome Associated with an Early Stress Stage in Male Wistar Rats: A Multi-Omics Approach. IJMS 2021;22:12931
    https://doi.org/10.3390/ijms222312931
  91. O.M. Voloshchuk, A.S. Boychuk. ACTIVITY OF KIDNEY MITOCHONDRIAL NAD+-DEPENDENT DEHYDROGENASES IN RATS UNDER CONDITIONS OF DIFFERENT NUTRIENT SUPPLY. Biolohichni systemy 2022;14:3
    https://doi.org/10.31861//biosystems2022.01.003
  92. Theerut Luangmonkong, Warisara Parichatikanond, Peter Olinga. Targeting collagen homeostasis for the treatment of liver fibrosis: Opportunities and challenges. Biochemical Pharmacology 2023;215:115740
    https://doi.org/10.1016/j.bcp.2023.115740
  93. Ines Sanchez-Roman, Sofie Lautrup, Maria Diget Aamann, Edward G. Neilan, John R. Østergaard, Tinna Stevnsner. Two Cockayne Syndrome patients with a novel splice site mutation – clinical and metabolic analyses. Mechanisms of Ageing and Development 2018;175:7
    https://doi.org/10.1016/j.mad.2018.06.001
  94. Aparna B. Baxi, Jie Li, Vi M. Quach, Leena R. Pade, Sally A. Moody, Peter Nemes. Cell lineage–guided mass spectrometry reveals increased energy metabolism and reactive oxygen species in the vertebrate organizer. Proc. Natl. Acad. Sci. U.S.A. 2024;121
    https://doi.org/10.1073/pnas.2311625121
  95. Hannes Gatterer, Thomas Böcksteiner, Alexander Müller, Helmut Simi, Christoph Krasser, Radosav Djukic, Rainer Schroth, Dietmar Wallner. 5-Hydroxymethylfurfural and Alpha-Ketoglutaric Acid as an Ergogenic Aid During Intensified Soccer Training: A Placebo Controlled Randomized Study. Journal of Dietary Supplements 2020;17:161
    https://doi.org/10.1080/19390211.2018.1494662
  96. Raymond D. Palmer. Three Tiers to biological escape velocity: The quest to outwit aging. Aging Medicine 2022;5:281
    https://doi.org/10.1002/agm2.12231
  97. Ruojing Liu, Yi Gao, Li Huang, Bing Shi, Xing Yin, Shujuan Zou. Alpha‐ketoglutarate up‐regulates autophagic activity in peri‐implant environment and enhances dental implant osseointegration in osteoporotic mice. J Clinic Periodontology 2023;50:671
    https://doi.org/10.1111/jcpe.13784
  98. Allison I. Daniel, Matilda E. Arvidsson Kvissberg, Edward Senga, Christian J. Versloot, Philliness Prisca Harawa, Wieger Voskuijl, David Wishart, Rupasri Mandal, Robert Bandsma, Céline Bourdon. Urinary Organic Acids Increase After Clinical Stabilization of Hospitalized Children With Severe Acute Malnutrition. Food Nutr Bull 2019;40:532
    https://doi.org/10.1177/0379572119853930
  99. Luyao Huang, Xiaodan Lu, Huadan Zhang, Baodong Zheng, Yi Zhang, Peng Liang. Effect of gut microbiota and metabolites in normal rats treated with large yellow croaker (Larimichthys crocea) roe phospholipids. Food Bioscience 2022;50:102132
    https://doi.org/10.1016/j.fbio.2022.102132
  100. Awanis Azizan, Leonie Venter, Peet J. Jansen van Rensburg, Jessica A. Ericson, Norman L. C. Ragg, Andrea C. Alfaro. Metabolite Changes of Perna canaliculus Following a Laboratory Marine Heatwave Exposure: Insights from Metabolomic Analyses. Metabolites 2023;13:815
    https://doi.org/10.3390/metabo13070815
  101. Nádia Weber Dimer, Bruna Klippel Ferreira, Jotele Fontana Agostini, Maria Luiza Gomes, Luiza Wilges Kist, Fernanda Malgarin, Milena Carvalho-Silva, Lara Mezari Gomes, Joyce Rebelo, Marisa Jádna Silva Frederico, Fátima Regina Mena Barreto Silva, Eduardo Pacheco Rico, Mauricio Reis Bogo, Emilio Luiz Streck, Gustavo Costa Ferreira, Patrícia Fernanda Schuck. Brain bioenergetics in rats with acute hyperphenylalaninemia. Neurochemistry International 2018;117:188
    https://doi.org/10.1016/j.neuint.2018.01.001
  102. Ewa Tomaszewska, Piotr Dobrowolski, Małgorzata Świątkiewicz, Janine Donaldson, Iwona Puzio, Siemowit Muszyński. Is Dietary 2-Oxoglutaric Acid Effective in Accelerating Bone Growth and Development in Experimentally-Induced Intrauterine Growth Retarded Gilts?. Animals 2020;10:728
    https://doi.org/10.3390/ani10040728
  103. Zhi-Rong Lin, Zhen-Zhen Li, Yan-Jun Cao, Wen-Jing Yu, Jian-Tao Ye, Pei-Qing Liu. GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of α-ketoglutarate level. Naunyn-Schmiedeberg's Arch Pharmacol 2022;395:1373
    https://doi.org/10.1007/s00210-022-02252-0
  104. Haitham H. Maraqah, Mones S. Abu-Asab, Han Sung Lee, Orwa Aboud. Comparative survey of mitochondrial ultrastructure in IDH1-mutant astrocytoma and IDH1-wildtype glioblastoma (GBM). Ultrastructural Pathology 2023;47:116
    https://doi.org/10.1080/01913123.2023.2175942
  105. Berrak Ugur, Huan Bao, Michal Stawarski, Lita R. Duraine, Zhongyuan Zuo, Yong Qi Lin, G. Gregory Neely, Gregory T. Macleod, Edwin R. Chapman, Hugo J. Bellen. The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Cell Reports 2017;21:3794
    https://doi.org/10.1016/j.celrep.2017.12.005
  106. Robbie S.J. Manuel, Yun Liang. Sexual dimorphism in immunometabolism and autoimmunity: Impact on personalized medicine. Autoimmunity Reviews 2021;20:102775
    https://doi.org/10.1016/j.autrev.2021.102775
  107. Jenna E. AbuSalim, Kazutoshi Yamamoto, Natsuko Miura, Burchelle Blackman, Jeffrey R. Brender, Chandrasekhar Mushti, Tomohiro Seki, Kevin A. Camphausen, Rolf E. Swenson, Murali C. Krishna, Aparna H. Kesarwala. Simple Esterification of [1-13C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine Production. ACS Chem. Biol. 2021;16:2144
    https://doi.org/10.1021/acschembio.1c00561
  108. Evan M. Zeitler, Yuanyuan Li, Madison Schroder, Ronald J. Falk, Susan Sumner. Characterizing the metabolic response of the zebrafish kidney to overfeeding. American Journal of Physiology-Renal Physiology 2023;325:F491
    https://doi.org/10.1152/ajprenal.00113.2023
  109. Donald L. Mykles, Ernest S. Chang. Hormonal control of the crustacean molting gland: Insights from transcriptomics and proteomics. General and Comparative Endocrinology 2020;294:113493
    https://doi.org/10.1016/j.ygcen.2020.113493
  110. Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin. Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biology 2021;41:101907
    https://doi.org/10.1016/j.redox.2021.101907
  111. Eytan M Stein. Enasidenib, a targeted inhibitor of mutant IDH2 proteins for treatment of relapsed or refractory acute myeloid leukemia. Future Oncology 2018;14:23
    https://doi.org/10.2217/fon-2017-0392
  112. . .
    https://doi.org/
  113. Siamak Tabibzadeh. Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins. Aging and disease 2022;13:1664
    https://doi.org/10.14336/AD.2022.0414
  114. Jorge L. Sanclemente, Sol M. Rivera‐Velez, David W. Horohov, Nairanjana Dasgupta, Macarena G. Sanz. Plasma metabolome of healthy and Rhodococcus equi‐infected foals over time. Equine Veterinary Journal 2023;55:831
    https://doi.org/10.1111/evj.13894
  115. Shelby Spring, Hasitha Premathilake, Udaya DeSilva, Cedrick Shili, Scott Carter, Adel Pezeshki. Low Protein-High Carbohydrate Diets Alter Energy Balance, Gut Microbiota Composition and Blood Metabolomics Profile in Young Pigs. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-60150-y
  116. Fuhang Song, Guoliang Zhang, Honghua Li, Linlin Ma, Na Yang. Comparative transcriptomic analysis of Stenotrophomonas sp. MNB17 revealed mechanisms of manganese tolerance at different concentrations and the role of histidine biosynthesis in manganese removal. Ecotoxicology and Environmental Safety 2022;244:114056
    https://doi.org/10.1016/j.ecoenv.2022.114056
  117. Fuchuan Guo, Mengyuan Han, Song Lin, Hui Ye, Jiedong Chen, Hongni Zhu, Wenting Lin. Enteromorpha prolifera polysaccharide prevents high‐ fat diet‐induced obesity in hamsters: A NMR‐based metabolomic evaluation. Journal of Food Science 2021;86:3672
    https://doi.org/10.1111/1750-3841.15818
  118. Tim Schnabel, Elizabeth Sattely, Gladys Alexandre. Engineering Posttranslational Regulation of Glutamine Synthetase for Controllable Ammonia Production in the Plant Symbiont Azospirillum brasilense. Appl Environ Microbiol 2021;87
    https://doi.org/10.1128/AEM.00582-21
  119. S. J. Kim, Y. Jo, S. J. Park, E. Ji, J. Y. Lee, E. Choi, J.-Y. Baek, I. Y. Jang, H.-W. Jung, K. Kim, D. Ryu, H. J. Yoo, B.-J. Kim. Metabolomic profiles of ovariectomized mice and their associations with body composition and frailty-related parameters in postmenopausal women. J Endocrinol Invest 2024
    https://doi.org/10.1007/s40618-024-02338-x
  120. Iryna Lushnikova, Olha Kostiuchenko, Magdalena Kowalczyk, Galyna Skibo. mTOR/α-ketoglutarate signaling: impact on brain cell homeostasis under ischemic conditions. Front. Cell. Neurosci. 2023;17
    https://doi.org/10.3389/fncel.2023.1132114
  121. Shan Cao, Yixuan Li, Rui Song, Xianyi Meng, Maximilian Fuchs, Chunguang Liang, Katerina Kachler, Xinyu Meng, Jinming Wen, Ursula Schlötzer-Schrehardt, Verena Taudte, Arne Gessner, Meik Kunz, Ulrike Schleicher, Mario M Zaiss, Alf Kastbom, Xiaoxiang Chen, Georg Schett, Aline Bozec. L-arginine metabolism inhibits arthritis and inflammatory bone loss. Ann Rheum Dis 2024;83:72
    https://doi.org/10.1136/ard-2022-223626
  122. Hongwei Guo, Shaojie Su, Catherine Madzak, Jingwen Zhou, Hongwen Chen, Guo Chen. Applying pathway engineering to enhance production of alpha-ketoglutarate in Yarrowia lipolytica. Appl Microbiol Biotechnol 2016;100:9875
    https://doi.org/10.1007/s00253-016-7913-x
  123. Simona Magi, Silvia Piccirillo, Marta Maiolino, Vincenzo Lariccia, Salvatore Amoroso. NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model. Cell Calcium 2020;91:102268
    https://doi.org/10.1016/j.ceca.2020.102268
  124. Hoang Dong Nguyen, Phedias Diamandis, Michelle S. Scott, Maxime Richer. Deciphering of Adult Glioma Vulnerabilities through Expression Pattern Analysis of GABA, Glutamate and Calcium Neurotransmitter Genes. JPM 2022;12:633
    https://doi.org/10.3390/jpm12040633
  125. Seo‐Young Park, Dong‐Hyuk Choi, Jinsung Song, Uiseon Park, Hyeran Cho, Bee Hak Hong, Yaron R. Silberberg, Dong‐Yup Lee. Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided analyses. Biotechnology Journal 2023;18
    https://doi.org/10.1002/biot.202300126
  126. Nitish Boodhoo, Nitin Kamble, Shayan Sharif, Shahriar Behboudi, Richard M. Longnecker. Glutaminolysis and Glycolysis Are Essential for Optimal Replication of Marek’s Disease Virus. J Virol 2020;94
    https://doi.org/10.1128/JVI.01680-19
  127. Ronald Lulijwa, Andrea C. Alfaro, Fabrice Merien, Mark Burdass, Jill Meyer, Leonie Venter, Tim Young. Polyinosinic:polycytidylic acid in vivo enhances Chinook salmon (Oncorhynchus tshawytscha) immunity and alters the fish metabolome. Aquacult Int 2020;28:2437
    https://doi.org/10.1007/s10499-020-00599-w
  128. E. Dervishi, T. Yang, M. K. Dyck, J. C. S. Harding, F. Fortin, J. Cheng, J. C. M. Dekkers, G. Plastow. Heritability and genetic correlations of plasma metabolites of pigs with production, resilience and carcass traits under natural polymicrobial disease challenge. Sci Rep 2021;11
    https://doi.org/10.1038/s41598-021-99778-9
  129. Silvana Valdebenito, Daniela D'Amico, Eliseo Eugenin. Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools. Cancer Reports 2019;2
    https://doi.org/10.1002/cnr2.1220
  130. Roland Taschner, Paul Gauss, Patrick Knaack, Robert Liska. Biocompatible photoinitiators based on poly‐α‐ketoesters. Journal of Polymer Science 2020;58:242
    https://doi.org/10.1002/pol.20199929
  131. Xinpei Sun, Qian Li, Yunyi Tang, Wanjin Hu, Gengyao Chen, Hongguang An, Daoyuan Huang, Tanjun Tong, Yu Zhang. Epigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling. Cell Death Dis 2023;14
    https://doi.org/10.1038/s41419-023-06002-9
  132. Dan Hao, Jiangsong Bai, Jianyong Du, Xiaoping Wu, Bo Thomsen, Hongding Gao, Guosheng Su, Xiao Wang. Overview of Metabolomic Analysis and the Integration with Multi-Omics for Economic Traits in Cattle. Metabolites 2021;11:753
    https://doi.org/10.3390/metabo11110753
  133. Sundeep S. Dhillon, Frida Torell, Magdalena Donten, Katrin Lundstedt-Enkel, Kate Bennett, Stefan Rännar, Johan Trygg, Torbjörn Lundstedt, Daniel Monleon. Metabolic profiling of zebrafish embryo development from blastula period to early larval stages. PLoS ONE 2019;14:e0213661
    https://doi.org/10.1371/journal.pone.0213661
  134. Yingying Zhang, Xiaotong Ji, Tingting Ku, Ben Li, Guangke Li, Nan Sang. Ambient fine particulate matter exposure induces cardiac functional injury and metabolite alterations in middle-aged female mice. Environmental Pollution 2019;248:121
    https://doi.org/10.1016/j.envpol.2019.01.080
  135. Yating Xu, Di Xia, Kai Huang, Minglu Liang. Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1. J Transl Med 2024;22
    https://doi.org/10.1186/s12967-024-04872-x
  136. Yexian Yuan, Pingwen Xu, Qingyan Jiang, Xingcai Cai, Tao Wang, Wentong Peng, Jiajie Sun, Canjun Zhu, Cha Zhang, Dong Yue, Zhihui He, Jinping Yang, Yuxian Zeng, Man Du, Fenglin Zhang, Lucas Ibrahimi, Sarah Schaul, Yuwei Jiang, Jiqiu Wang, Jia Sun, Qiaoping Wang, Liming Liu, Songbo Wang, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Cong Yin, Fan Li, Guli Xu, Yongliang Zhang, Gang Shu. Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation. The EMBO Journal 2020;39
    https://doi.org/10.15252/embj.2019103304
  137. Xin Wen, Tsz Kin Ng, Qingping Liu, Zhenggen Wu, Guihua Zhang, Mingzhi Zhang. Azelaic acid and guanosine in tears improve discrimination of proliferative from non-proliferative diabetic retinopathy in type-2 diabetes patients: A tear metabolomics study. Heliyon 2023;9:e16109
    https://doi.org/10.1016/j.heliyon.2023.e16109
  138. Samuel Sutiono, André Pick, Volker Sieber. Converging conversion – using promiscuous biocatalysts for the cell-free synthesis of chemicals from heterogeneous biomass. Green Chem. 2021;23:3656
    https://doi.org/10.1039/D0GC04288A
  139. Melissa Van de Gucht, Inès Dufait, Lisa Kerkhove, Cyril Corbet, Sven de Mey, Heng Jiang, Ka Lun Law, Thierry Gevaert, Olivier Feron, Mark De Ridder. Inhibition of Phosphoglycerate Dehydrogenase Radiosensitizes Human Colorectal Cancer Cells under Hypoxic Conditions. Cancers 2022;14:5060
    https://doi.org/10.3390/cancers14205060
  140. Anita Rywińska, Ludwika Tomaszewska-Hetman, Magdalena Rakicka-Pustułka, Piotr Juszczyk, Waldemar Rymowicz. Alpha-Ketoglutaric Acid Production from a Mixture of Glycerol and Rapeseed Oil by Yarrowia lipolytica Using Different Substrate Feeding Strategies. Sustainability 2020;12:6109
    https://doi.org/10.3390/su12156109
  141. Gerwyn Morris, Maria Gevezova, Victoria Sarafian, Michael Maes. Redox regulation of the immune response. Cell Mol Immunol 2022;19:1079
    https://doi.org/10.1038/s41423-022-00902-0
  142. Elizabeth Cabrera, Laylah C. Welch, Meaghan R. Robinson, Candyce M. Sturgeon, Mackenzie M. Crow, Verónica A. Segarra. Cryopreservation and the Freeze–Thaw Stress Response in Yeast. Genes 2020;11:835
    https://doi.org/10.3390/genes11080835
  143. Ke Liu, Yafei Wu, Wenqin Yang, Tianlong Li, Zhongxu Wang, Shu Xiao, Zhenghua Peng, Meng Li, Wenhao Xiong, Meixiang Li, Xi Chen, Shun Zhang, Xiaocan Lei. α‐Ketoglutarate Improves Ovarian Reserve Function in Primary Ovarian Insufficiency by Inhibiting NLRP3‐Mediated Pyroptosis of Granulosa Cells. Molecular Nutrition Food Res 2024;68
    https://doi.org/10.1002/mnfr.202300784
  144. Nina Miljanovic, Roelof Maarten van Dijk, Verena Buchecker, Heidrun Potschka. Metabolomic signature of the Dravet syndrome: A genetic mouse model study. Epilepsia 2021;62:2000
    https://doi.org/10.1111/epi.16976
  145. Cho Hyun Kim, Hyun Jung Lee, Doo Yeon Jung, Minsu Kim, Hyun Young Jung, Heesang Hong, Yun-Sang Choi, Hae In Yong, Cheorun Jo. Evaluation of fermented soybean meal and edible insect hydrolysates as potential serum replacement in pig muscle stem cell culture. Food Bioscience 2023;54:102923
    https://doi.org/10.1016/j.fbio.2023.102923
  146. Stefan Pierzynowski, Kateryna Pierzynowska. Alpha-ketoglutarate, a key molecule involved in nitrogen circulation in both animals and plants, in the context of human gut microbiota and protein metabolism. Advances in Medical Sciences 2022;67:142
    https://doi.org/10.1016/j.advms.2022.02.004
  147. Joslyn L. Mangal, Sahil Inamdar, Tien Le, Xiaojian Shi, Marion Curtis, Haiwei Gu, Abhinav P. Acharya. Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice. Biomaterials 2021;277:121079
    https://doi.org/10.1016/j.biomaterials.2021.121079
  148. Linda Keil, Norbert Mehlmer, Philipp Cavelius, Daniel Garbe, Martina Haack, Manfred Ritz, Dania Awad, Thomas Brück. The Time-Resolved Salt Stress Response of Dunaliella tertiolecta—A Comprehensive System Biology Perspective. IJMS 2023;24:15374
    https://doi.org/10.3390/ijms242015374
  149. Yuanlin Zhao, Ying Yang, Risheng Yang, Chao Sun, Xing Gao, Xiwen Gu, Yuan Yuan, Yating Nie, Shenhui Xu, Ruili Han, Lijun Zhang, Jing Li, Peizhen Hu, Yingmei Wang, Huangtao Chen, Xiangmei Cao, Jing Wu, Zhe Wang, Yu Gu, Jing Ye. IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbing α-ketoglutarate-related metabolism and epigenetic modification. 2024;3
    https://doi.org/10.1093/lifemeta/loae002
  150. Fan He, Angelo B.A. Laranjeira, Tim Kong, Shuyang Lin, Katrina J. Ashworth, Alice Liu, Nina M. Lasky, Daniel A.C. Fisher, Maggie J. Cox, Mary C. Fulbright, Lilian Antunes-Heck, LaYow Yu, Molly Brakhane, Bei Gao, Stephen M. Sykes, Angelo D’Alessandro, Jorge Di Paola, Stephen T. Oh. Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms. 2024;134
    https://doi.org/10.1172/JCI172256
  151. Yuanyuan Zhai, Jia Xu, Li Feng, Qinan Liu, Weifeng Yao, Hui Li, Yudan Cao, Fangfang Cheng, Beihua Bao, Li Zhang. Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine. Journal of Ethnopharmacology 2019;234:57
    https://doi.org/10.1016/j.jep.2019.01.019
  152. Constantine A. Simintiras, José M. Sánchez, Michael McDonald, Patrick Lonergan. The influence of progesterone on bovine uterine fluid energy, nucleotide, vitamin, cofactor, peptide, and xenobiotic composition during the conceptus elongation-initiation window. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-44040-6
  153. Christopher Q. Rogers, Melissa Ramirez, Carol S. Landon, Janine M. DeBlasi, Andrew P. Koutnik, Csilla Ari, Dominic P. D’Agostino. A Glutamate Scavenging Protocol Combined with Deanna Protocol in SOD1-G93A Mouse Model of ALS. Nutrients 2023;15:1821
    https://doi.org/10.3390/nu15081821
  154. Henning Wackerhage, Brad J. Schoenfeld, D. Lee Hamilton, Maarit Lehti, Juha J. Hulmi. Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise. Journal of Applied Physiology 2019;126:30
    https://doi.org/10.1152/japplphysiol.00685.2018
  155. Liuqin He, Xihong Zhou, Niu Huang, Huan Li, Zhijie Cui, Junquan Tian, Qian Jiang, Shaojuan Liu, Jian Wu, Tiejun Li, Kang Yao, Yulong Yin. Administration of alpha-ketoglutarate improves epithelial restitution under stress injury in early-weaning piglets. Oncotarget 2017;8:91965
    https://doi.org/10.18632/oncotarget.20555
  156. Tuba REÇBER, Emirhan NEMUTLU, Emine AYDIN, Murat CAGAN, Hanife Güler DÖNMEZ, Sedef KIR, M.sinan BEKSAC. Metabolic Infrastructure of Pregnant Women with Fetuses Having Nervous System Abnormalities; Metabolomic Analysis. 2023;44:236
    https://doi.org/10.17776/csj.1246590
  157. Monika Chopra, Vikas Kumar, Manoj Singh, Neeraj K. Aggarwal. An overview about the approaches used in the production of alpha-ketoglutaric acid with their applications. 2024;9:211
    https://doi.org/10.1515/psr-2022-0162
  158. Alejandro Bravo Iniguez, Min Du, Mei-Jun Zhu. α-Ketoglutarate for Preventing and Managing Intestinal Epithelial Dysfunction. Advances in Nutrition 2024;15:100200
    https://doi.org/10.1016/j.advnut.2024.100200
  159. Anna Nieborak, Robert Schneider. Metabolic intermediates – Cellular messengers talking to chromatin modifiers. Molecular Metabolism 2018;14:39
    https://doi.org/10.1016/j.molmet.2018.01.007
  160. Muhammad Idrees, Afzal R. Mohammad, Nazira Karodia, Ayesha Rahman. Multimodal Role of Amino Acids in Microbial Control and Drug Development. Antibiotics 2020;9:330
    https://doi.org/10.3390/antibiotics9060330
  161. Alex MacLean, Anondo Bley, Vasu D. Appanna. Microbial and Natural Macromolecules. 2020.
    https://doi.org/10.1016/B978-0-12-820084-1.00005-3
  162. Zhengyang Kang, Bin Wu, Luhui Zhang, Xinzhi Liang, Dong Guo, Shuai Yuan, Denghui Xie. Metabolic regulation by biomaterials in osteoblast. Front. Bioeng. Biotechnol. 2023;11
    https://doi.org/10.3389/fbioe.2023.1184463
  163. Vaishali Gupta, Chris Major Ncho, Akshat Goel, Chae-Mi Jeong, Yang-Ho Choi. In ovo feeding of α-ketoglutaric acid improves hepatic antioxidant-gene expression, plasma antioxidant activities and decreases body temperature without affecting broiler body weight under cyclic heat stress. Poultry Science 2024:103749
    https://doi.org/10.1016/j.psj.2024.103749
  164. V. Tkachenko, Y. Kovalchuk, N. Bondarenko, О. Bondarenko, G. Ushakova, A. Shevtsova. The Cardio- and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage. Biochemistry Research International 2018;2018:1
    https://doi.org/10.1155/2018/9302414
  165. Lin-Lin Pan, Qi-Hui Sun, Gui-Rong Liu, Jia-Yin Guo. Urinary Metabolomics Study of the Intervention Effect of Hypoglycemic Decoction on Type 2 Diabetes Mellitus Rats Model. Evidence-Based Complementary and Alternative Medicine 2019;2019:1
    https://doi.org/10.1155/2019/1394641
  166. Ana Carolina B. Sant’Anna-Silva, Juan A. Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T. Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker. Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells. Cancers 2021;13:1727
    https://doi.org/10.3390/cancers13071727
  167. Tommaso Pizzorusso, Paola Tognini. Interplay between Metabolism, Nutrition and Epigenetics in Shaping Brain DNA Methylation, Neural Function and Behavior. Genes 2020;11:742
    https://doi.org/10.3390/genes11070742
  168. Sangyong Lee, Hyuk Soon Kim, Myoung Jun Kim, Keun Young Min, Wahn Soo Choi, Jueng Soo You. Glutamine metabolite α-ketoglutarate acts as an epigenetic co-factor to interfere with osteoclast differentiation. Bone 2021;145:115836
    https://doi.org/10.1016/j.bone.2020.115836
  169. Azhar A. Alhasawi, Sean C. Thomas, Sujeethar Tharmalingam, Felix Legendre, Vasu D. Appanna. Isocitrate Lyase and Succinate Semialdehyde Dehydrogenase Mediate the Synthesis of α-Ketoglutarate in Pseudomonas fluorescens. Front. Microbiol. 2019;10
    https://doi.org/10.3389/fmicb.2019.01929
  170. Samuel Sutiono, Bettina Siebers, Volker Sieber. Characterization of highly active 2-keto-3-deoxy-L-arabinonate and 2-keto-3-deoxy-D-xylonate dehydratases in terms of the biotransformation of hemicellulose sugars to chemicals. Appl Microbiol Biotechnol 2020;104:7023
    https://doi.org/10.1007/s00253-020-10742-5
  171. Bo-Yeong Yu, Da-Hae Eom, Hyun Woo Kim, Yong-Joo Jeong, Young-Sam Keum. Dimethyl α-Ketoglutarate Promotes the Synthesis of Collagen and Inhibits Metalloproteinases in HaCaT Cells. Biomol Ther (Seoul) 2024;32:240
    https://doi.org/10.4062/biomolther.2023.131
  172. Ewa Tomaszewska, Natalia Burmańczuk, Piotr Dobrowolski, Małgorzata Świątkiewicz, Janine Donaldson, Artur Burmańczuk, Maria Mielnik-Błaszczak, Damian Kuc, Szymon Milewski, Siemowit Muszyński. The Protective Role of Alpha-Ketoglutaric Acid on the Growth and Bone Development of Experimentally Induced Perinatal Growth-Retarded Piglets. Animals 2021;11:137
    https://doi.org/10.3390/ani11010137
  173. Yufei Zhang, Jiacheng Hu, Peisong Lu, Ru Yang, Xu-Fang Liang, Liwei Liu. Addition of α-ketoglutaric acid (AKG) reduces deamination in Chinese perch (Siniperca chuatsi) fed with fermented soybean meal as a substitute for fishmeal. Fish Physiol Biochem 2024
    https://doi.org/10.1007/s10695-024-01312-x
  174. Laura F. Grogan, Jacques Robert, Lee Berger, Lee F. Skerratt, Benjamin C. Scheele, J. Guy Castley, David A. Newell, Hamish I. McCallum. Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions. Front. Immunol. 2018;9
    https://doi.org/10.3389/fimmu.2018.02536
  175. André Luis Fernandes Lopes, Andreza Ketly da Silva Araújo, Letícia de Sousa Chaves, Gabriella Pacheco, Ana Patrícia de Oliveira, Katriane Carvalho da Silva, Antonio Carlos Pereira de Oliveira, Cristhyane Costa de Aquino, Marcelo Biondaro Gois, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros. Protective effect of alpha-ketoglutarate against water-immersion restraint stress-induced gastric mucosal damage in mice. European Journal of Pharmacology 2023;960:176118
    https://doi.org/10.1016/j.ejphar.2023.176118
  176. Ji-Hee Haam, Yun Kyong Lee, Eunkyung Suh, Sang-Woon Choi, Hyejin Chun, Young-Sang Kim. Urine organic acids may be useful biomarkers for metabolic syndrome and its components in Korean adults. 2021;59:1824
    https://doi.org/10.1515/cclm-2021-0598
  177. Marcus VL Dos Santos Quaresma, Camila Maria de Melo, Sandra Maria Lima Ribeiro. Effect of proteins, amino acids, and other nitrogenated supplements on the skeletal muscle mass in people living with HIV (PLWH): A systematic review. Clinical Nutrition ESPEN 2022;51:160
    https://doi.org/10.1016/j.clnesp.2022.07.001
  178. Madhan M. C. S. Jaggarapu, Deepanjan Ghosh, Tyler Johnston, Jordan R. Yaron, Joslyn L. Mangal, Sahil Inamdar, Mallikarjun Gosangi, Kaushal Rege, Abhinav P. Acharya. Alpha‐ketoglutaric acid based polymeric particles for cutaneous wound healing. J Biomedical Materials Res 2023;111:1372
    https://doi.org/10.1002/jbm.a.37539
  179. M. Bajo-Fernández, G. Montero, V. Alonso-Herranz, C. Barbas, F. Rey-Stolle, A. García. Structural elucidation of derivatives of polyfunctional metabolites after methyl chloroformate derivatization by high-resolution mass spectrometry gas chromatography. Application to microbiota metabolites. Journal of Chromatography A 2024;1717:464656
    https://doi.org/10.1016/j.chroma.2024.464656
  180. Katsuya Nagaoka, Joud Mulla, Kevin Cao, Zhixiang Cheng, Dan Liu, William Mueller, Amalia Bay, Grace Hildebrand, Shaolei Lu, Chiung-Kuei Huang. The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism. Liver Research 2020;4:94
    https://doi.org/10.1016/j.livres.2020.04.001
  181. S. A. Kehinde, A. Ore, A. T. Olajide, T. P. Fatokun, O. P. Akano. Diisononyl phthalate negatively perturbs testicular energy metabolism and histoarchitecture of rats. Journal of Hazardous Materials Advances 2022;8:100153
    https://doi.org/10.1016/j.hazadv.2022.100153
  182. Ming-xiang Cheng, Ding Cao, Yong Chen, Jin-zheng Li, Bing Tu, Jian-ping Gong. α-ketoglutarate attenuates ischemia-reperfusion injury of liver graft in rats. Biomedicine & Pharmacotherapy 2019;111:1141
    https://doi.org/10.1016/j.biopha.2018.12.149
  183. Seo‐Young Park, Thomas M. Reimonn, Cyrus D. Agarabi, Kurt A. Brorson, Seongkyu Yoon. Metabolic responses and pathway changes of mammalian cells under different culture conditions with media supplementations. Biotechnology Progress 2018;34:793
    https://doi.org/10.1002/btpr.2623