Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Cited by CrossRef (116)

  1. M. Lylyk, O. Sorochynska, O. Maniukh, M. Bayliak. Gender differences of amino acid metabolism in Drosophila melanogaster on alpha-ketoglutarate-supplemented food. BTSNUKSPPFR 2016;21:31
    https://doi.org/10.17721/2616_6410.2016.21.31-36
  2. G. Morris, K. R. Walder, M. Berk, W. Marx, A. J. Walker, M. Maes, B. K. Puri. The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?. Mol Biol Rep 2020;47:5587
    https://doi.org/10.1007/s11033-020-05590-5
  3. Laetitia Gibart, Rajeev Khoodeeram, Gilles Bernot, Jean-Paul Comet, Jean-Yves Trosset. Regulation of Eukaryote Metabolism: An Abstract Model Explaining the Warburg/Crabtree Effect. Processes 2021;9:1496
    https://doi.org/10.3390/pr9091496
  4. Bibek Gyanwali, Zi Xiang Lim, Janjira Soh, Clarissa Lim, Shou Ping Guan, Jorming Goh, Andrea B. Maier, Brian K. Kennedy. Alpha-Ketoglutarate dietary supplementation to improve health in humans. Trends in Endocrinology & Metabolism 2022;33:136
    https://doi.org/10.1016/j.tem.2021.11.003
  5. Andre Catic. Metabolic Aspects of Aging. 2022.
    https://doi.org/10.1016/bs.pmbts.2017.12.003
  6. P. Mara, G. S. Fragiadakis, F. Gkountromichos, D. Alexandraki. The pleiotropic effects of the glutamate dehydrogenase (GDH) pathway in Saccharomyces cerevisiae. Microb Cell Fact 2018;17
    https://doi.org/10.1186/s12934-018-1018-4
  7. Laura F. Grogan, Lee F. Skerratt, Lee Berger, Scott D. Cashins, Robert D. Trengove, Joel P. A. Gummer. Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathways. Sci Rep 2018;8
    https://doi.org/10.1038/s41598-018-26427-z
  8. Qian Jiang, Liuqin He, Yongqing Hou, Jiashun Chen, Yehui Duan, Dun Deng, Guoyao Wu, Yulong Yin, Kang Yao. Alpha-ketoglutarate enhances milk protein synthesis by porcine mammary epithelial cells. Amino Acids 2016;48:2179
    https://doi.org/10.1007/s00726-016-2249-5
  9. Sabine Mann, Joshua D. Ramsay, Joseph J. Wakshlag, Tracy Stokol, Steven Reed, Thomas J. Divers. Investigating the pathogenesis of high‐serum gamma‐glutamyl transferase activity in Thoroughbred racehorses: A series of case‐control studies. Equine Vet J 2022;54:39
    https://doi.org/10.1111/evj.13435
  10. Udit Gupta, Tung Le, Wei-Shou Hu, Aditya Bhan, Prodromos Daoutidis. Automated network generation and analysis of biochemical reaction pathways using RING. Metabolic Engineering 2018;49:84
    https://doi.org/10.1016/j.ymben.2018.07.009
  11. Tomasz Niemiec, Klara Zglińska, Wiesław Świderek, Weronika Górecka, Magdalena Matusiewicz, Andrzej Łozicki, Iwona Kosieradzka, Stefan Pierzynowski. The effect of alpha-ketoglutarate (AKG) on the behaviour of ageing laboratory mice. 2018;14:31
    https://doi.org/10.5604/01.3001.0013.5081
  12. Fan Wu, Xuexia Xie, Guoliang Li, Dongping Bao, Haomin Li, Guohao Wu, Yiqi Lai, Yaping Xing, Peng Ouyang, Guo Chen, Zhifeng Wang, Caiyong Lai. AKG induces cell apoptosis by inducing reactive oxygen species‐mediated endoplasmic reticulum stress and by suppressing PI3K / AKT / mTOR ‐mediated autophagy in renal cell carcinoma . Environmental Toxicology 2022
    https://doi.org/10.1002/tox.23658
  13. Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H. Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn. Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis. Nat Commun 2020;11
    https://doi.org/10.1038/s41467-020-19959-4
  14. Eduardo Izquierdo-Torres, Andrés Hernández-Oliveras, Dalia Lozano-Arriaga, Ángel Zarain-Herzberg. Obesity, the other pandemic: linking diet and carcinogenesis by epigenetic mechanisms. The Journal of Nutritional Biochemistry 2022;108:109092
    https://doi.org/10.1016/j.jnutbio.2022.109092
  15. Oleksandr Demidenko, Diogo Barardo, Valery Budovskii, Robb Finnemore, Francis R. Palmer, Brian K. Kennedy, Yelena V. Budovskaya. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging 2021;13:24485
    https://doi.org/10.18632/aging.203736
  16. Okon Dominic Ekpe, Gyojin Choo, Younghun Choi, Junho Jeon, Jeong-Eun Oh. Long-term degradation of toluene and phenol in soil: Identification of transformation products and pathways via HRMS-based suspect and non-target screening. Journal of Hazardous Materials 2022;430:128429
    https://doi.org/10.1016/j.jhazmat.2022.128429
  17. Zhengtao Liu, Junsheng Zhao, Wenchao Wang, Hai Zhu, Junjie Qian, Shuai Wang, Shuping Que, Feng Zhang, Shengyong Yin, Lin Zhou, Lei Geng, Shusen Zheng, Xianquan Zhan. Integrative Network Analysis Revealed Genetic Impact of Pyruvate Kinase L/R on Hepatocyte Proliferation and Graft Survival after Liver Transplantation. Oxidative Medicine and Cellular Longevity 2021;2021:1
    https://doi.org/10.1155/2021/7182914
  18. Rishi Sharma, Arvind Ramanathan. The Aging Metabolome—Biomarkers to Hub Metabolites. Proteomics 2020;20:1800407
    https://doi.org/10.1002/pmic.201800407
  19. Xue Zhang, Ning Xu, Jialong Li, Zhenping Ma, Liang Wei, Qingdai Liu, Jun Liu. Engineering of L-glutamate oxidase as the whole-cell biocatalyst for the improvement of α-ketoglutarate production. Enzyme and Microbial Technology 2020;136:109530
    https://doi.org/10.1016/j.enzmictec.2020.109530
  20. Matteo Antoine Negroni, Francisca H. I. D. Segers, Fanny Vogelweith, Susanne Foitzik. Immune challenge reduces gut microbial diversity and triggers fertility-dependent gene expression changes in a social insect. BMC Genomics 2020;21
    https://doi.org/10.1186/s12864-020-07191-9
  21. Suhail Razak, Tayyaba Afsar, Dara Al-Disi, Ali Almajwal, Mohammed Arshad, Abdullah A. Alyousef, Rukaya Amin Chowdary. GCMS fingerprinting, in vitro pharmacological activities, and in vivo anti-inflammatory and hepatoprotective effect of selected edible herbs from Kashmir valley. Journal of King Saud University - Science 2020;32:2868
    https://doi.org/10.1016/j.jksus.2020.07.011
  22. Katherine J. Wert, Gabriel Velez, Vijaya L. Kanchustambham, Vishnu Shankar, Lucy P. Evans, Jesse D. Sengillo, Richard N. Zare, Alexander G. Bassuk, Stephen H. Tsang, Vinit B. Mahajan. Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration. EBioMedicine 2020;52:102636
    https://doi.org/10.1016/j.ebiom.2020.102636
  23. Alexandros Grivas, George Fragoulis, Panagiotis Garantziotis, Aggelos Banos, Elena Nikiphorou, Dimitrios Boumpas. Unraveling the complexities of psoriatic arthritis by the use of -Omics and their relevance for clinical care. Autoimmunity Reviews 2021;20:102949
    https://doi.org/10.1016/j.autrev.2021.102949
  24. Wei Liu, Yaoting Sun, Weigang Ge, Fangfei Zhang, Lin Gan, Yi Zhu, Tiannan Guo, Kexin Liu. DIA-Based Proteomics Identifies IDH2 as a Targetable Regulator of Acquired Drug Resistance in Chronic Myeloid Leukemia. Molecular & Cellular Proteomics 2022;21:100187
    https://doi.org/10.1016/j.mcpro.2021.100187
  25. Diego Camuzi, Ísis de Amorim, Luis Ribeiro Pinto, Leonardo Oliveira Trivilin, André Mencalha, Sheila Soares Lima. Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer. Cells 2019;8:300
    https://doi.org/10.3390/cells8040300
  26. Jie Zhao, Cen Xie, Xiyan Mu, Kristopher W. Krausz, Daxesh P. Patel, Xiaowei Shi, Xiaoxia Gao, Qiao Wang, Frank J. Gonzalez. Metabolic alterations in triptolide-induced acute hepatotoxicity. Biomedical Chromatography 2018;32:e4299
    https://doi.org/10.1002/bmc.4299
  27. Mengyao Shi, Jiang He, Changwei Li, Xiangfeng Lu, William J. He, Jie Cao, Jing Chen, Ji-Chun Chen, Lydia A. Bazzano, Jian-Xin Li, Hua He, Dongfeng Gu, Tanika N. Kelly. Metabolomics study of blood pressure salt-sensitivity and hypertension. Nutrition, Metabolism and Cardiovascular Diseases 2022;32:1681
    https://doi.org/10.1016/j.numecd.2022.04.002
  28. Daniel G Tenen, Li Chai, Justin L Tan. Metabolic alterations and vulnerabilities in hepatocellular carcinoma. 2021;9:1
    https://doi.org/10.1093/gastro/goaa066
  29. Cedric Wüthrich, Miguel de Figueiredo, Kathryn Jane Burton-Pimentel, Guy Vergères, Fabian Wahl, Renato Zenobi, Stamatios Giannoukos. Breath response following a nutritional challenge monitored by secondary electrospray ionization high-resolution mass spectrometry. J. Breath Res. 2022;16:046007
    https://doi.org/10.1088/1752-7163/ac894e
  30. Piotr Dobrowolski, Ewa Tomaszewska, Siemowit Muszyński, Tomasz Blicharski, Stefan G Pierzynowski. Dietary 2-oxoglutarate prevents bone loss caused by neonatal treatment with maximal dexamethasone dose. Exp Biol Med (Maywood) 2017;242:671
    https://doi.org/10.1177/1535370217693322
  31. Yanfeng Liu, Long Liu. Systems and Synthetic Biotechnology for Production of Nutraceuticals. 2017.
    https://doi.org/10.1007/978-981-15-0446-4_1
  32. Hailang He, Tingyu Pan, Xiaojian Shi, Shuang Yang, Paniz Jasbi, Yan Jin, Julia Yue Cui, Haiwei Gu. An integrative cellular metabolomic study reveals downregulated tricarboxylic acid cycle and potential biomarkers induced by tetrabromobisphenol A in human lung A549 cells . Environmental Toxicology 2022
    https://doi.org/10.1002/tox.23657
  33. Di Wu, Ze Fan, Jinnan Li, Yuanyuan Zhang, Qiyou Xu, Liang Wang, Liansheng Wang. Low Protein Diets Supplemented With Alpha-Ketoglutarate Enhance the Growth Performance, Immune Response, and Intestinal Health in Common Carp (Cyprinus carpio). Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.915657
  34. Ni Lian, Li-Qing Shi, Zhi-Min Hao, Min Chen. Research progress and perspective in metabolism and metabolomics of psoriasis. 2020;133:2976
    https://doi.org/10.1097/CM9.0000000000001242
  35. Ewa Tomaszewska, Sylwester Świątkiewicz, Anna Arczewska-Włosek, Dorota Wojtysiak, Piotr Dobrowolski, Piotr Domaradzki, Izabela Świetlicka, Janine Donaldson, Monika Hułas-Stasiak, Siemowit Muszyński. Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study. Animals 2020;10:2420
    https://doi.org/10.3390/ani10122420
  36. Ewa Tomaszewska, Anna Arczewska-Włosek, Artur Burmańczuk, Renata Pyz-Łukasik, Janine Donaldson, Siemowit Muszyński, Sylwester Świątkiewicz. The Effect of L-Glutamine on Basal Albumen and Yolk Indices, and Albumen Amino Acids Composition. Animals 2021;11:3556
    https://doi.org/10.3390/ani11123556
  37. Shuhan Lei, Bingru Huang. Metabolic regulation of α-Ketoglutarate associated with heat tolerance in perennial ryegrass. Plant Physiology and Biochemistry 2022;190:164
    https://doi.org/10.1016/j.plaphy.2022.09.005
  38. Yan Han, Xingping Quan, Yaochen Chuang, Qiaoxing Liang, Yang Li, Zhen Yuan, Ying Bian, Lai Wei, Ji Wang, Yonghua Zhao. A multi‐omics analysis for the prediction of neurocognitive disorders risk among the elderly in Macao. Clinical & Translational Med 2022;12
    https://doi.org/10.1002/ctm2.909
  39. Chaitra Surugihalli, Tom E. Porter, Angela Chan, Linda S. Farley, Meghan Maguire, Christine Zhang, Nathan Kattapuram, Muhammed S. Muyyarikkandy, Hsiao-Ching Liu, Nishanth E. Sunny. Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-56715-1
  40. Elise Malard, Samuel Valable, Myriam Bernaudin, Elodie Pérès, Laurent Chatre. The Reactive Species Interactome in the Brain. Antioxidants & Redox Signaling 2021;35:1176
    https://doi.org/10.1089/ars.2020.8238
  41. Yuling Ma, Sumei Zhou, Jing Lu. Metabolomic Analysis Reveals Changes of Bioactive Compounds in Mung Beans (Vigna radiata) during γ-Aminobutyric Acid Enrichment Treatment. Foods 2022;11:1423
    https://doi.org/10.3390/foods11101423
  42. Weichuan Xiong, Alexander Perna, Ikechukwu B. Jacob, Benjamin R. Lundgren, Guirong Wang, Igor E. Brodsky. The Enhancer-Binding Protein MifR, an Essential Regulator of α-Ketoglutarate Transport, Is Required for Full Virulence of Pseudomonas aeruginosa PAO1 in a Mouse Model of Pneumonia. Infect Immun 2022
    https://doi.org/10.1128/iai.00136-22
  43. Natsuko Miura, Chandrasekhar Mushti, Deepak Sail, Jenna E. AbuSalim, Kazutoshi Yamamoto, Jeffrey R. Brender, Tomohiro Seki, Deyaa I. AbuSalim, Shingo Matsumoto, Kevin A. Camphausen, Murali C. Krishna, Rolf E. Swenson, Aparna H. Kesarwala. Synthesis of [1‐ 13 C‐5‐ 12 C]‐alpha‐ketoglutarate enables noninvasive detection of 2‐hydroxyglutarate . NMR in Biomedicine 2021;34
    https://doi.org/10.1002/nbm.4588
  44. Ewa Tomaszewska, Siemowit Muszyński, Anna Arczewska-Włosek, Piotr Domaradzki, Renata Pyz-Łukasik, Janine Donaldson, Sylwester Świątkiewicz. Cholesterol Content, Fatty Acid Profile and Health Lipid Indices in the Egg Yolk of Eggs from Hens at the End of the Laying Cycle, Following Alpha-Ketoglutarate Supplementation. Foods 2021;10:596
    https://doi.org/10.3390/foods10030596
  45. Sofiya Gancheva, Tomas Jelenik, Elisa Álvarez-Hernández, Michael Roden. Interorgan Metabolic Crosstalk in Human Insulin Resistance. Physiological Reviews 2018;98:1371
    https://doi.org/10.1152/physrev.00015.2017
  46. Laura F. Grogan, Josephine E. Humphries, Jacques Robert, Chantal M. Lanctôt, Catherine J. Nock, David A. Newell, Hamish I. McCallum. Immunological Aspects of Chytridiomycosis. JoF 2020;6:234
    https://doi.org/10.3390/jof6040234
  47. Abubakar Sha’aban, Hadzliana Zainal, Nor Azlina Khalil, Fatimatuzzahra’ Abd Aziz, Ewe Seng Ch’ng, Chin-Hoe Teh, Mustapha Mohammed, Baharudin Ibrahim. Prediction of Low-Dose Aspirin-Induced Gastric Toxicity Using Nuclear Magnetic Resonance Spectroscopy-Based Pharmacometabolomics in Rats. Molecules 2022;27:2126
    https://doi.org/10.3390/molecules27072126
  48. Isabella Corsato Alvarenga, Charles Aldrich, Dennis Jewell. Influence of Liver Condition and Copper on Selective Parameters of Post-Mortem Dog Tissue Samples. Animals 2018;8:237
    https://doi.org/10.3390/ani8120237
  49. F. Legendre, A. MacLean, V. P. Appanna, V. D. Appanna. Biochemical pathways to α-ketoglutarate, a multi-faceted metabolite. World J Microbiol Biotechnol 2020;36
    https://doi.org/10.1007/s11274-020-02900-8
  50. Silvia Piccirillo, Simona Magi, Pasqualina Castaldo, Alessandra Preziuso, Vincenzo Lariccia, Salvatore Amoroso. NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival. Cell Calcium 2020;86:102160
    https://doi.org/10.1016/j.ceca.2020.102160
  51. Xiao Wang, Haja N. Kadarmideen. Metabolomics Analyses in High-Low Feed Efficient Dairy Cows Reveal Novel Biochemical Mechanisms and Predictive Biomarkers. Metabolites 2019;9:151
    https://doi.org/10.3390/metabo9070151
  52. Lijing Guo, Shihua Chen, Liping Ou, Shangmei Li, Zhen-Nan Ye, Hua-Feng Liu. Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond. DMSO 2022;Volume 15:1961
    https://doi.org/10.2147/DMSO.S369090
  53. Pengfei Cui, Caihua Huang, Jiaqi Guo, Qianwen Wang, Zhiqing Liu, Huiqin Zhuo, Donghai Lin. Metabolic Profiling of Tumors, Sera, and Skeletal Muscles from an Orthotopic Murine Model of Gastric Cancer Associated-Cachexia. J. Proteome Res. 2019;18:1880
    https://doi.org/10.1021/acs.jproteome.9b00088
  54. Lige Xiao, Guanteng Yang, Hongqi Zhang, Jinyang Liu, Chaofeng Guo, Yang Sun, Shuai Chen. Nontargeted Metabolomic Analysis of Plasma Metabolite Changes in Patients with Adolescent Idiopathic Scoliosis. Mediators of Inflammation 2021;2021:1
    https://doi.org/10.1155/2021/5537811
  55. Saud Alamri, Qasi D. Alsubaie, Abdullah A. Al‐Amri, Bandar Al‐Munqedi, Hayssam M. Ali, Bishwajit K. Kushwaha, Vijay P. Singh, Manzer H. Siddiqui. Priming of tomato seedlings with 2‐oxoglutarate induces arsenic toxicity alleviatory responses by involving endogenous nitric oxide. Physiol Plantarum 2020
    https://doi.org/10.1111/ppl.13168
  56. Wei-Lin Tu, Chuen-Yu Cheng, Chao-Jung Chen, Hong-Lin Chan, Shih-Han Wang, Pin-Chi Tang, Chih-Feng Chen, Yen-Pai Lee, Shuen-Ei Chen, San-Yuan Huang. Annotation of differential protein expression in the hypothalami of layer-type Taiwan country chickens in response to acute heat stress. Journal of Thermal Biology 2018;77:157
    https://doi.org/10.1016/j.jtherbio.2018.08.013
  57. Julia Hernandez-Baixauli, Pere Puigbò, Nerea Abasolo, Hector Palacios-Jordan, Elisabet Foguet-Romero, David Suñol, Mar Galofré, Antoni Caimari, Laura Baselga-Escudero, Josep M. Del Bas, Miquel Mulero. Alterations in Metabolome and Microbiome Associated with an Early Stress Stage in Male Wistar Rats: A Multi-Omics Approach. IJMS 2021;22:12931
    https://doi.org/10.3390/ijms222312931
  58. Ines Sanchez-Roman, Sofie Lautrup, Maria Diget Aamann, Edward G. Neilan, John R. Østergaard, Tinna Stevnsner. Two Cockayne Syndrome patients with a novel splice site mutation – clinical and metabolic analyses. Mechanisms of Ageing and Development 2018;175:7
    https://doi.org/10.1016/j.mad.2018.06.001
  59. Hannes Gatterer, Thomas Böcksteiner, Alexander Müller, Helmut Simi, Christoph Krasser, Radosav Djukic, Rainer Schroth, Dietmar Wallner. 5-Hydroxymethylfurfural and Alpha-Ketoglutaric Acid as an Ergogenic Aid During Intensified Soccer Training: A Placebo Controlled Randomized Study. Journal of Dietary Supplements 2020;17:161
    https://doi.org/10.1080/19390211.2018.1494662
  60. Allison I. Daniel, Matilda E. Arvidsson Kvissberg, Edward Senga, Christian J. Versloot, Philliness Prisca Harawa, Wieger Voskuijl, David Wishart, Rupasri Mandal, Robert Bandsma, Céline Bourdon. Urinary Organic Acids Increase After Clinical Stabilization of Hospitalized Children With Severe Acute Malnutrition. Food Nutr Bull 2019;40:532
    https://doi.org/10.1177/0379572119853930
  61. Nádia Weber Dimer, Bruna Klippel Ferreira, Jotele Fontana Agostini, Maria Luiza Gomes, Luiza Wilges Kist, Fernanda Malgarin, Milena Carvalho-Silva, Lara Mezari Gomes, Joyce Rebelo, Marisa Jádna Silva Frederico, Fátima Regina Mena Barreto Silva, Eduardo Pacheco Rico, Mauricio Reis Bogo, Emilio Luiz Streck, Gustavo Costa Ferreira, Patrícia Fernanda Schuck. Brain bioenergetics in rats with acute hyperphenylalaninemia. Neurochemistry International 2018;117:188
    https://doi.org/10.1016/j.neuint.2018.01.001
  62. Ewa Tomaszewska, Piotr Dobrowolski, Małgorzata Świątkiewicz, Janine Donaldson, Iwona Puzio, Siemowit Muszyński. Is Dietary 2-Oxoglutaric Acid Effective in Accelerating Bone Growth and Development in Experimentally-Induced Intrauterine Growth Retarded Gilts?. Animals 2020;10:728
    https://doi.org/10.3390/ani10040728
  63. Zhi-Rong Lin, Zhen-Zhen Li, Yan-Jun Cao, Wen-Jing Yu, Jian-Tao Ye, Pei-Qing Liu. GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of α-ketoglutarate level. Naunyn-Schmiedeberg's Arch Pharmacol 2022
    https://doi.org/10.1007/s00210-022-02252-0
  64. Berrak Ugur, Huan Bao, Michal Stawarski, Lita R. Duraine, Zhongyuan Zuo, Yong Qi Lin, G. Gregory Neely, Gregory T. Macleod, Edwin R. Chapman, Hugo J. Bellen. The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission. Cell Reports 2017;21:3794
    https://doi.org/10.1016/j.celrep.2017.12.005
  65. Robbie S.J. Manuel, Yun Liang. Sexual dimorphism in immunometabolism and autoimmunity: Impact on personalized medicine. Autoimmunity Reviews 2021;20:102775
    https://doi.org/10.1016/j.autrev.2021.102775
  66. Jenna E. AbuSalim, Kazutoshi Yamamoto, Natsuko Miura, Burchelle Blackman, Jeffrey R. Brender, Chandrasekhar Mushti, Tomohiro Seki, Kevin A. Camphausen, Rolf E. Swenson, Murali C. Krishna, Aparna H. Kesarwala. Simple Esterification of [1-13C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine Production. ACS Chem. Biol. 2021;16:2144
    https://doi.org/10.1021/acschembio.1c00561
  67. Donald L. Mykles, Ernest S. Chang. Hormonal control of the crustacean molting gland: Insights from transcriptomics and proteomics. General and Comparative Endocrinology 2020;294:113493
    https://doi.org/10.1016/j.ygcen.2020.113493
  68. Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin. Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biology 2021;41:101907
    https://doi.org/10.1016/j.redox.2021.101907
  69. Eytan M Stein. Enasidenib, a targeted inhibitor of mutant IDH2 proteins for treatment of relapsed or refractory acute myeloid leukemia. Future Oncology 2018;14:23
    https://doi.org/10.2217/fon-2017-0392
  70. . .
    https://doi.org/
  71. Shelby Spring, Hasitha Premathilake, Udaya DeSilva, Cedrick Shili, Scott Carter, Adel Pezeshki. Low Protein-High Carbohydrate Diets Alter Energy Balance, Gut Microbiota Composition and Blood Metabolomics Profile in Young Pigs. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-60150-y
  72. Fuhang Song, Guoliang Zhang, Honghua Li, Linlin Ma, Na Yang. Comparative transcriptomic analysis of Stenotrophomonas sp. MNB17 revealed mechanisms of manganese tolerance at different concentrations and the role of histidine biosynthesis in manganese removal. Ecotoxicology and Environmental Safety 2022;244:114056
    https://doi.org/10.1016/j.ecoenv.2022.114056
  73. Fuchuan Guo, Mengyuan Han, Song Lin, Hui Ye, Jiedong Chen, Hongni Zhu, Wenting Lin. Enteromorpha prolifera polysaccharide prevents high‐ fat diet‐induced obesity in hamsters: A NMR‐based metabolomic evaluation . Journal of Food Science 2021;86:3672
    https://doi.org/10.1111/1750-3841.15818
  74. Tim Schnabel, Elizabeth Sattely, Gladys Alexandre. Engineering Posttranslational Regulation of Glutamine Synthetase for Controllable Ammonia Production in the Plant Symbiont Azospirillum brasilense. Appl Environ Microbiol 2021;87
    https://doi.org/10.1128/AEM.00582-21
  75. Hongwei Guo, Shaojie Su, Catherine Madzak, Jingwen Zhou, Hongwen Chen, Guo Chen. Applying pathway engineering to enhance production of alpha-ketoglutarate in Yarrowia lipolytica. Appl Microbiol Biotechnol 2016;100:9875
    https://doi.org/10.1007/s00253-016-7913-x
  76. Simona Magi, Silvia Piccirillo, Marta Maiolino, Vincenzo Lariccia, Salvatore Amoroso. NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model. Cell Calcium 2020;91:102268
    https://doi.org/10.1016/j.ceca.2020.102268
  77. Hoang Dong Nguyen, Phedias Diamandis, Michelle S. Scott, Maxime Richer. Deciphering of Adult Glioma Vulnerabilities through Expression Pattern Analysis of GABA, Glutamate and Calcium Neurotransmitter Genes. JPM 2022;12:633
    https://doi.org/10.3390/jpm12040633
  78. Nitish Boodhoo, Nitin Kamble, Shayan Sharif, Shahriar Behboudi, Richard M. Longnecker. Glutaminolysis and Glycolysis Are Essential for Optimal Replication of Marek’s Disease Virus. J Virol 2020;94
    https://doi.org/10.1128/JVI.01680-19
  79. Ronald Lulijwa, Andrea C. Alfaro, Fabrice Merien, Mark Burdass, Jill Meyer, Leonie Venter, Tim Young. Polyinosinic:polycytidylic acid in vivo enhances Chinook salmon (Oncorhynchus tshawytscha) immunity and alters the fish metabolome. Aquacult Int 2020;28:2437
    https://doi.org/10.1007/s10499-020-00599-w
  80. E. Dervishi, T. Yang, M. K. Dyck, J. C. S. Harding, F. Fortin, J. Cheng, J. C. M. Dekkers, G. Plastow. Heritability and genetic correlations of plasma metabolites of pigs with production, resilience and carcass traits under natural polymicrobial disease challenge. Sci Rep 2021;11
    https://doi.org/10.1038/s41598-021-99778-9
  81. Silvana Valdebenito, Daniela D'Amico, Eliseo Eugenin. Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools. Cancer Reports 2019;2
    https://doi.org/10.1002/cnr2.1220
  82. Roland Taschner, Paul Gauss, Patrick Knaack, Robert Liska. Biocompatible photoinitiators based on poly‐α‐ketoesters. Journal of Polymer Science 2020;58:242
    https://doi.org/10.1002/pol.20199929
  83. Dan Hao, Jiangsong Bai, Jianyong Du, Xiaoping Wu, Bo Thomsen, Hongding Gao, Guosheng Su, Xiao Wang. Overview of Metabolomic Analysis and the Integration with Multi-Omics for Economic Traits in Cattle. Metabolites 2021;11:753
    https://doi.org/10.3390/metabo11110753
  84. Sundeep S. Dhillon, Frida Torell, Magdalena Donten, Katrin Lundstedt-Enkel, Kate Bennett, Stefan Rännar, Johan Trygg, Torbjörn Lundstedt, Daniel Monleon. Metabolic profiling of zebrafish embryo development from blastula period to early larval stages. PLoS ONE 2019;14:e0213661
    https://doi.org/10.1371/journal.pone.0213661
  85. Yingying Zhang, Xiaotong Ji, Tingting Ku, Ben Li, Guangke Li, Nan Sang. Ambient fine particulate matter exposure induces cardiac functional injury and metabolite alterations in middle-aged female mice. Environmental Pollution 2019;248:121
    https://doi.org/10.1016/j.envpol.2019.01.080
  86. Yexian Yuan, Pingwen Xu, Qingyan Jiang, Xingcai Cai, Tao Wang, Wentong Peng, Jiajie Sun, Canjun Zhu, Cha Zhang, Dong Yue, Zhihui He, Jinping Yang, Yuxian Zeng, Man Du, Fenglin Zhang, Lucas Ibrahimi, Sarah Schaul, Yuwei Jiang, Jiqiu Wang, Jia Sun, Qiaoping Wang, Liming Liu, Songbo Wang, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Cong Yin, Fan Li, Guli Xu, Yongliang Zhang, Gang Shu. Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation. EMBO J 2020;39
    https://doi.org/10.15252/embj.2019103304
  87. Samuel Sutiono, André Pick, Volker Sieber. Converging conversion – using promiscuous biocatalysts for the cell-free synthesis of chemicals from heterogeneous biomass. Green Chem. 2021;23:3656
    https://doi.org/10.1039/D0GC04288A
  88. Anita Rywińska, Ludwika Tomaszewska-Hetman, Magdalena Rakicka-Pustułka, Piotr Juszczyk, Waldemar Rymowicz. Alpha-Ketoglutaric Acid Production from a Mixture of Glycerol and Rapeseed Oil by Yarrowia lipolytica Using Different Substrate Feeding Strategies. Sustainability 2020;12:6109
    https://doi.org/10.3390/su12156109
  89. Gerwyn Morris, Maria Gevezova, Victoria Sarafian, Michael Maes. Redox regulation of the immune response. Cell Mol Immunol 2022;19:1079
    https://doi.org/10.1038/s41423-022-00902-0
  90. Elizabeth Cabrera, Laylah C. Welch, Meaghan R. Robinson, Candyce M. Sturgeon, Mackenzie M. Crow, Verónica A. Segarra. Cryopreservation and the Freeze–Thaw Stress Response in Yeast. Genes 2020;11:835
    https://doi.org/10.3390/genes11080835
  91. Nina Miljanovic, Roelof Maarten van Dijk, Verena Buchecker, Heidrun Potschka. Metabolomic signature of the Dravet syndrome: A genetic mouse model study. Epilepsia 2021;62:2000
    https://doi.org/10.1111/epi.16976
  92. Stefan Pierzynowski, Kateryna Pierzynowska. Alpha-ketoglutarate, a key molecule involved in nitrogen circulation in both animals and plants, in the context of human gut microbiota and protein metabolism. Advances in Medical Sciences 2022;67:142
    https://doi.org/10.1016/j.advms.2022.02.004
  93. Joslyn L. Mangal, Sahil Inamdar, Tien Le, Xiaojian Shi, Marion Curtis, Haiwei Gu, Abhinav P. Acharya. Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice. Biomaterials 2021;277:121079
    https://doi.org/10.1016/j.biomaterials.2021.121079
  94. Yuanyuan Zhai, Jia Xu, Li Feng, Qinan Liu, Weifeng Yao, Hui Li, Yudan Cao, Fangfang Cheng, Beihua Bao, Li Zhang. Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine. Journal of Ethnopharmacology 2019;234:57
    https://doi.org/10.1016/j.jep.2019.01.019
  95. Constantine A. Simintiras, José M. Sánchez, Michael McDonald, Patrick Lonergan. The influence of progesterone on bovine uterine fluid energy, nucleotide, vitamin, cofactor, peptide, and xenobiotic composition during the conceptus elongation-initiation window. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-44040-6
  96. Henning Wackerhage, Brad J. Schoenfeld, D. Lee Hamilton, Maarit Lehti, Juha J. Hulmi. Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise. Journal of Applied Physiology 2019;126:30
    https://doi.org/10.1152/japplphysiol.00685.2018
  97. Liuqin He, Xihong Zhou, Niu Huang, Huan Li, Zhijie Cui, Junquan Tian, Qian Jiang, Shaojuan Liu, Jian Wu, Tiejun Li, Kang Yao, Yulong Yin. Administration of alpha-ketoglutarate improves epithelial restitution under stress injury in early-weaning piglets. Oncotarget 2017;8:91965
    https://doi.org/10.18632/oncotarget.20555
  98. Monika Chopra, Vikas Kumar, Manoj Singh, Neeraj K. Aggarwal. An overview about the approaches used in the production of alpha-ketoglutaric acid with their applications. 2022
    https://doi.org/10.1515/psr-2022-0162
  99. Anna Nieborak, Robert Schneider. Metabolic intermediates – Cellular messengers talking to chromatin modifiers. Molecular Metabolism 2018;14:39
    https://doi.org/10.1016/j.molmet.2018.01.007
  100. Muhammad Idrees, Afzal R. Mohammad, Nazira Karodia, Ayesha Rahman. Multimodal Role of Amino Acids in Microbial Control and Drug Development. Antibiotics 2020;9:330
    https://doi.org/10.3390/antibiotics9060330
  101. Alex MacLean, Anondo Bley, Vasu D. Appanna. Microbial and Natural Macromolecules. 2020.
    https://doi.org/10.1016/B978-0-12-820084-1.00005-3
  102. V. Tkachenko, Y. Kovalchuk, N. Bondarenko, О. Bondarenko, G. Ushakova, A. Shevtsova. The Cardio- and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage. Biochemistry Research International 2018;2018:1
    https://doi.org/10.1155/2018/9302414
  103. Lin-Lin Pan, Qi-Hui Sun, Gui-Rong Liu, Jia-Yin Guo. Urinary Metabolomics Study of the Intervention Effect of Hypoglycemic Decoction on Type 2 Diabetes Mellitus Rats Model. Evidence-Based Complementary and Alternative Medicine 2019;2019:1
    https://doi.org/10.1155/2019/1394641
  104. Ana Carolina B. Sant’Anna-Silva, Juan A. Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T. Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker. Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells. Cancers 2021;13:1727
    https://doi.org/10.3390/cancers13071727
  105. Tommaso Pizzorusso, Paola Tognini. Interplay between Metabolism, Nutrition and Epigenetics in Shaping Brain DNA Methylation, Neural Function and Behavior. Genes 2020;11:742
    https://doi.org/10.3390/genes11070742
  106. Sangyong Lee, Hyuk Soon Kim, Myoung Jun Kim, Keun Young Min, Wahn Soo Choi, Jueng Soo You. Glutamine metabolite α-ketoglutarate acts as an epigenetic co-factor to interfere with osteoclast differentiation. Bone 2021;145:115836
    https://doi.org/10.1016/j.bone.2020.115836
  107. Azhar A. Alhasawi, Sean C. Thomas, Sujeethar Tharmalingam, Felix Legendre, Vasu D. Appanna. Isocitrate Lyase and Succinate Semialdehyde Dehydrogenase Mediate the Synthesis of α-Ketoglutarate in Pseudomonas fluorescens. Front. Microbiol. 2019;10
    https://doi.org/10.3389/fmicb.2019.01929
  108. Samuel Sutiono, Bettina Siebers, Volker Sieber. Characterization of highly active 2-keto-3-deoxy-L-arabinonate and 2-keto-3-deoxy-D-xylonate dehydratases in terms of the biotransformation of hemicellulose sugars to chemicals. Appl Microbiol Biotechnol 2020;104:7023
    https://doi.org/10.1007/s00253-020-10742-5
  109. Ewa Tomaszewska, Natalia Burmańczuk, Piotr Dobrowolski, Małgorzata Świątkiewicz, Janine Donaldson, Artur Burmańczuk, Maria Mielnik-Błaszczak, Damian Kuc, Szymon Milewski, Siemowit Muszyński. The Protective Role of Alpha-Ketoglutaric Acid on the Growth and Bone Development of Experimentally Induced Perinatal Growth-Retarded Piglets. Animals 2021;11:137
    https://doi.org/10.3390/ani11010137
  110. Laura F. Grogan, Jacques Robert, Lee Berger, Lee F. Skerratt, Benjamin C. Scheele, J. Guy Castley, David A. Newell, Hamish I. McCallum. Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions. Front. Immunol. 2018;9
    https://doi.org/10.3389/fimmu.2018.02536
  111. Ji-Hee Haam, Yun Kyong Lee, Eunkyung Suh, Sang-Woon Choi, Hyejin Chun, Young-Sang Kim. Urine organic acids may be useful biomarkers for metabolic syndrome and its components in Korean adults. 2021;59:1824
    https://doi.org/10.1515/cclm-2021-0598
  112. Marcus VL Dos Santos Quaresma, Camila Maria de Melo, Sandra Maria Lima Ribeiro. Effect of proteins, amino acids, and other nitrogenated supplements on the skeletal muscle mass in people living with HIV (PLWH): A systematic review. Clinical Nutrition ESPEN 2022;51:160
    https://doi.org/10.1016/j.clnesp.2022.07.001
  113. Katsuya Nagaoka, Joud Mulla, Kevin Cao, Zhixiang Cheng, Dan Liu, William Mueller, Amalia Bay, Grace Hildebrand, Shaolei Lu, Chiung-Kuei Huang. The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism. Liver Research 2020;4:94
    https://doi.org/10.1016/j.livres.2020.04.001
  114. S. A. Kehinde, A. Ore, A. T. Olajide, T. P. Fatokun, O. P. Akano. Diisononyl phthalate negatively perturbs testicular energy metabolism and histoarchitecture of rats. Journal of Hazardous Materials Advances 2022;8:100153
    https://doi.org/10.1016/j.hazadv.2022.100153
  115. Ming-xiang Cheng, Ding Cao, Yong Chen, Jin-zheng Li, Bing Tu, Jian-ping Gong. α-ketoglutarate attenuates ischemia-reperfusion injury of liver graft in rats. Biomedicine & Pharmacotherapy 2019;111:1141
    https://doi.org/10.1016/j.biopha.2018.12.149
  116. Seo-Young Park, Thomas M. Reimonn, Cyrus D. Agarabi, Kurt A. Brorson, Seongkyu Yoon. Metabolic responses and pathway changes of mammalian cells under different culture conditions with media supplementations. Biotechnol Progress 2018;34:793
    https://doi.org/10.1002/btpr.2623