Biomolecules & Therapeutics : eISSN 2005-4483 / pISSN 1976-9148

Cited by CrossRef (54)

  1. Akash Ahuja, Deok Jeong, Mi-Yeon Kim, Jae Youl Cho. Trichosanthes tricuspidata Lour. Methanol Extract Exhibits Anti-Inflammatory Activity by Targeting Syk, Src, and IRAK1 Kinase Activity. Evidence-Based Complementary and Alternative Medicine 2019;2019:1
    https://doi.org/10.1155/2019/6879346
  2. Liang Liu, Shouyi Gan, Bin Li, Xiong Ge, Hui Yu, Huiliang Zhou. Fisetin Alleviates Atrial Inflammation, Remodeling, and Vulnerability to Atrial Fibrillation after Myocardial Infarction. Int. Heart J. 2019;60:1398
    https://doi.org/10.1536/ihj.19-131
  3. Abdur Rauf, Tareq Abu-Izneid, Muhammad Imran, Hassan A. Hemeg, Kashif Bashir, Abdullah S.M. Aljohani, Mona S.M. Aljohani, Fahad A. Alhumaydhi, Ishaq N. Khan, Talha Bin Emran, Tanweer Aslam Gondal, Nikhil Nath, Ishtiaque Ahmad, Muthu Thiruvengadam. Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin. CTMC 2023;23:2075
    https://doi.org/10.2174/1568026623666230710162217
  4. Thamaraiselvan Rengarajan, Nik Soriani Yaacob. The flavonoid fisetin as an anticancer agent targeting the growth signaling pathways. European Journal of Pharmacology 2016;789:8
    https://doi.org/10.1016/j.ejphar.2016.07.001
  5. Ashok Kumar Mandal, Ankit Sahoo, Khusbu Dwivedi, Richa Singh, Vikas Kumar. Potential therapeutic application of biophenols – plants secondary metabolites in rheumatoid arthritis. Critical Reviews in Food Science and Nutrition 2023;63:8900
    https://doi.org/10.1080/10408398.2022.2062700
  6. Qingling Fan, Xiaoye Wang, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Qingkui Wang. Fisetin suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats via enhancing the apoptotic signaling pathway. Journal of King Saud University - Science 2020;32:1959
    https://doi.org/10.1016/j.jksus.2020.01.042
  7. Rina Das, Dinesh Kumar Mehta, Meenakshi Dhanawat. Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors. MRMC 2022;22:1938
    https://doi.org/10.2174/1389557522666220307170126
  8. Raushanara Akter, Md. Rashidur Rahman, Zainab Syed Ahmed, Afrina Afrose. Plausibility of natural immunomodulators in the treatment of COVID-19–A comprehensive analysis and future recommendations. Heliyon 2023;9:e17478
    https://doi.org/10.1016/j.heliyon.2023.e17478
  9. Harish C. Pal, Ross L. Pearlman, Farrukh Afaq. Anti-inflammatory Nutraceuticals and Chronic Diseases. 2023.
    https://doi.org/10.1007/978-3-319-41334-1_10
  10. Arun Reddy Ravula, Suraj Benerji Teegala, Shanker Kalakotla, Jagadeesh Prasad Pasangulapati, Venkatesan Perumal, Hemanth Kumar Boyina. Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review. European Journal of Pharmacology 2021;910:174492
    https://doi.org/10.1016/j.ejphar.2021.174492
  11. Syed Shams ul Hassan, Saptadip Samanta, Raju Dash, Tomasz M. Karpiński, Emran Habibi, Abdul Sadiq, Amirhossein Ahmadi, Simona Bungau. The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress. Front. Pharmacol. 2022;13
    https://doi.org/10.3389/fphar.2022.1015835
  12. Sareshma Sudhesh Dev, Reyhaneh Farghadani, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu. Flavonoids as receptor tyrosine kinase inhibitors in lung cancer. Journal of Functional Foods 2023;110:105845
    https://doi.org/10.1016/j.jff.2023.105845
  13. Yue Sun, Hong Qin, Huihui Zhang, Xiangling Feng, Lina Yang, De-Xing Hou, Jihua Chen. Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells. Food & Nutrition Research 2021;65
    https://doi.org/10.29219/fnr.v65.6355
  14. Sulgi Yoo, Mi-Yeon Kim, Jae Youl Cho. Beauvericin, a cyclic peptide, inhibits inflammatory responses in macrophages by inhibiting the NF-κB pathway. Korean J Physiol Pharmacol 2017;21:449
    https://doi.org/10.4196/kjpp.2017.21.4.449
  15. Tao Ma, Amit D. Kandhare, Anwesha A. Mukherjee-Kandhare, Subhash L. Bodhankar. Fisetin, a plant flavonoid ameliorates doxorubicin-induced cardiotoxicity in experimental rats: the decisive role of caspase-3, COX-II, cTn-I, iNOs and TNF-α. Mol Biol Rep 2019;46:105
    https://doi.org/10.1007/s11033-018-4450-y
  16. Woo Seok Yang, Eunju Yang, Min-Jeong Kim, Deok Jeong, Deok Hyo Yoon, Gi-Ho Sung, Seungihm Lee, Byong Chul Yoo, Seung-Gu Yeo, Jae Youl Cho. Momordica charantia Inhibits Inflammatory Responses in Murine Macrophages via Suppression of TAK1. Am. J. Chin. Med. 2018;46:435
    https://doi.org/10.1142/S0192415X18500222
  17. Federica Frezzato, Flavia Raggi, Veronica Martini, Filippo Severin, Valentina Trimarco, Andrea Visentin, Edoardo Scomazzon, Benedetta Accordi, Silvia Bresolin, Francesco Piazza, Monica Facco, Giuseppe Basso, Gianpietro Semenzato, Livio Trentin. HSP70/HSF1 axis, regulated via a PI3K/AKT pathway, is a druggable target in chronic lymphocytic leukemia. Intl Journal of Cancer 2019;145:3089
    https://doi.org/10.1002/ijc.32383
  18. Woo Seok Yang, Donghyun Kim, Young-Su Yi, Ji Hye Kim, Hye Yoon Jeong, Kyeonghwan Hwang, Jong-Hoon Kim, Junseong Park, Jae Youl Cho. AKT-targeted anti-inflammatory activity of the methanol extract of Chrysanthemum indicum var. albescens. Journal of Ethnopharmacology 2017;201:82
    https://doi.org/10.1016/j.jep.2017.03.001
  19. Jing Cui, Jingshi Fan, Huanxia Li, Jinku Zhang, Jianzhou Tong. Neuroprotective potential of fisetin in an experimental model of spinal cord injury: via modulation of NF-κB/IκBα pathway. 2021;32:296
    https://doi.org/10.1097/WNR.0000000000001596
  20. Navid Jamali, Ehsan Heidari Soureshjani, Gholam-Reza Mobini, Mohammad Samare-Najaf, Cain C. T. Clark, Javad Saffari-Chaleshtori. Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: anin silicostudy. Journal of Biomolecular Structure and Dynamics 2022;40:8073
    https://doi.org/10.1080/07391102.2021.1906749
  21. Bin Wang, Yan Ding, Penghui Zhao, Wei Li, Ming Li, Jingbo Zhu, Shuhong Ye. Systems pharmacology-based drug discovery and active mechanism of natural products for coronavirus pneumonia (COVID-19): An example using flavonoids. Computers in Biology and Medicine 2022;143:105241
    https://doi.org/10.1016/j.compbiomed.2022.105241
  22. Jung-Eun Kim, Hengmin Han, Yinzhu Xu, Min-Ho Lee, Hyo-Jeong Lee. Efficacy of FRO on Acne Vulgaris Pathogenesis. Pharmaceutics 2023;15:1885
    https://doi.org/10.3390/pharmaceutics15071885
  23. Jinfeng Yang, Yong Soo Kwon, Myong Jo Kim. Antimicrobial activity and active compounds of a Rhus verniciflua Stokes extract. 2018;73:457
    https://doi.org/10.1515/znc-2018-0054
  24. Young-Su Yi, Jae Youl Cho, Daewon Kim. Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway. Journal of Ethnopharmacology 2016;193:387
    https://doi.org/10.1016/j.jep.2016.08.033
  25. Woo Seok Yang, Gyeong Sug Nam, Mi-Yeon Kim, Jae Youl Cho. Syk-Mediated Suppression of Inflammatory Responses by Cordyceps bassiana. Am. J. Chin. Med. 2017;45:1217
    https://doi.org/10.1142/S0192415X17500677
  26. Jae Sik Yu, Jun Ho Kim, Seulah Lee, Kiwon Jung, Ki Hyun Kim, Jae Youl Cho. Src/Syk-Targeted Anti-Inflammatory Actions of Triterpenoidal Saponins from Gac (Momordica cochinchinensis) Seeds. Am. J. Chin. Med. 2017;45:459
    https://doi.org/10.1142/S0192415X17500288
  27. Jeong-Oog Lee, Woo Seok Yang, Jae Gwang Park, Deok Jeong, Han Gyung Kim, Kee Dong Yoon, Adithan Aravinthan, Jong-Hoon Kim, Eunji Kim, Jae Youl Cho. Src and Syk contribute to the anti-inflammatory activities of Achyranthes aspera ethanolic extract. Journal of Ethnopharmacology 2017;206:1
    https://doi.org/10.1016/j.jep.2017.05.013
  28. Qian Ren, Fan Guo, Sibei Tao, Rongshuang Huang, Liang Ma, Ping Fu. Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice. Biomedicine & Pharmacotherapy 2020;122:109772
    https://doi.org/10.1016/j.biopha.2019.109772
  29. Han Gyung Kim, Nak Yoon Sung, Ji Hye Kim, Jae Youl Cho. In vitro anti-cancer effects of beauvericin through inhibition of actin polymerization and Src phosphorylation. Phytomedicine 2023;109:154573
    https://doi.org/10.1016/j.phymed.2022.154573
  30. Yedam Moon, Hayeong Kim, Choon Gil Kang, Chanho Park, Seung Wook Kim, Doman Kim. Biochemical characterization of synthesized fisetin glucoside by dextransucrase from Leuconostoc mesenteroides NRRL B-1299CB4 with enhanced water solubility. Enzyme and Microbial Technology 2022;161:110111
    https://doi.org/10.1016/j.enzmictec.2022.110111
  31. You Jin Kim, Jeong Deok, Sunggyu Kim, Deok Hyo Yoon, Gi-Ho Sung, Adithan Aravinthan, Seungihm Lee, Mi-nam Lee, Suntaek Hong, Jong-Hoon Kim, Young-Jin Son, Jae Youl Cho. Anti-Inflammatory Effect of Piper attenuatum Methanol Extract in LPS-Stimulated Inflammatory Responses. Evidence-Based Complementary and Alternative Medicine 2017;2017:1
    https://doi.org/10.1155/2017/4606459
  32. Ilandarage Menu Neelaka Molagoda, Chang-Hee Kang, Mi-Hwa Lee, Yung Hyun Choi, Chang-Min Lee, Seungheon Lee, Gi-Young Kim. Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation, inhibiting osteoporosis. Biochemical Pharmacology 2021;192:114676
    https://doi.org/10.1016/j.bcp.2021.114676
  33. Jozaa Z. ALTamimi, Mona N. BinMowyna, Nora A. AlFaris, Reham I. Alagal, Attalla F. El-kott, Ammar M. AL-Farga. Fisetin protects against streptozotocin-induced diabetic cardiomyopathy in rats by suppressing fatty acid oxidation and inhibiting protein kinase R. Saudi Pharmaceutical Journal 2021;29:27
    https://doi.org/10.1016/j.jsps.2020.12.003
  34. Eunji Kim, Young-Gyu Kang, Yong-Jin Kim, Tae Ryong Lee, Byong Chul Yoo, Minkyeong Jo, Ji Hye Kim, Jong-Hoon Kim, Donghyun Kim, Jae Youl Cho. Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. IJMS 2019;20:1593
    https://doi.org/10.3390/ijms20071593
  35. Hanne Vissenaekens, Hanne Criel, Charlotte Grootaert, Katleen Raes, Guy Smagghe, John Van Camp. Flavonoids and cellular stress: a complex interplay affecting human health. Critical Reviews in Food Science and Nutrition 2022;62:8535
    https://doi.org/10.1080/10408398.2021.1929822
  36. Johnna F. Varghese, Rohit Patel, Mohit Singh, Umesh C. S. Yadav. Fisetin Prevents Oxidized Low-density Lipoprotein–Induced Macrophage Foam Cell Formation. 2021;78:e729
    https://doi.org/10.1097/FJC.0000000000001096
  37. Dharambir Kashyap, Vivek Kumar Garg, Hardeep Singh Tuli, Mukerrem Betul Yerer, Katrin Sak, Anil Kumar Sharma, Manoj Kumar, Vaishali Aggarwal, Sardul Singh Sandhu. Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential. Biomolecules 2019;9:174
    https://doi.org/10.3390/biom9050174
  38. Brandon M. Hall, Anatoli S. Gleiberman, Evguenia Strom, Peter A. Krasnov, David Frescas, Slavoljub Vujcic, Olga V. Leontieva, Marina P. Antoch, Valeria Kogan, Igor E. Koman, Yi Zhu, Tamara Tchkonia, James L. Kirkland, Olga B. Chernova, Andrei V. Gudkov. Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue. Aging Cell 2020;19
    https://doi.org/10.1111/acel.13219
  39. Yiying Wang, Xiaoyu Wang, Kexin Su, Yifu Yang. Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases. CCDT 2023;23:751
    https://doi.org/10.2174/1568009623666230426093244
  40. Cagla Eren Cimenci, Nick J. R. Blackburn, Veronika Sedlakova, Justina Pupkaite, Marcelo Munoz, Benjamin H. Rotstein, David A. Spiegel, Emilio I. Alarcon, Erik J. Suuronen. Combined Methylglyoxal Scavenger and Collagen Hydrogel Therapy Prevents Adverse Remodeling and Improves Cardiac Function Post‐Myocardial Infarction. Adv Funct Materials 2022;32
    https://doi.org/10.1002/adfm.202108630
  41. Kwang-Soo Baek, Young-Su Yi, Young-Jin Son, Sulgi Yoo, Nak Yoon Sung, Yong Kim, Sungyoul Hong, Adithan Aravinthan, Jong-Hoon Kim, Jae Youl Cho. In vitro and in vivo anti-inflammatory activities of Korean Red Ginseng-derived components. Journal of Ginseng Research 2016;40:437
    https://doi.org/10.1016/j.jgr.2016.08.003
  42. Han Gyung Kim, Subin Choi, Jongsung Lee, Yo Han Hong, Deok Jeong, Keejung Yoon, Deok Hyo Yoon, Gi-Ho Sung, Seungihm Lee, Suntaek Hong, Young-Su Yi, Jong-Hoon Kim, Jae Youl Cho. Src Is a Prime Target Inhibited by Celtis choseniana Methanol Extract in Its Anti-Inflammatory Action. Evidence-Based Complementary and Alternative Medicine 2018;2018:1
    https://doi.org/10.1155/2018/3909038
  43. Muhammad Jahangir Hossen, Woo Seok Yang, Daewon Kim, Adithan Aravinthan, Jong-Hoon Kim, Jae Youl Cho. Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. Sci Rep 2017;7
    https://doi.org/10.1038/srep42995
  44. Ilandarage Menu Neelaka Molagoda, Mirissa Hewage Dumindu Kavinda, Yung Hyun Choi, Hyesook Lee, Chang-Hee Kang, Mi-Hwa Lee, Chang-Min Lee, Gi-Young Kim. Fisetin Protects HaCaT Human Keratinocytes from Fine Particulate Matter (PM2.5)-Induced Oxidative Stress and Apoptosis by Inhibiting the Endoplasmic Reticulum Stress Response. Antioxidants 2021;10:1492
    https://doi.org/10.3390/antiox10091492
  45. Seong-Gu Jeong, Sunggyu Kim, Han Gyung Kim, Eunji Kim, Deok Jeong, Ji Hye Kim, Woo Seok Yang, Junsang Oh, Gi-Ho Sung, Mohammad Amjad Hossain, Jongsung Lee, Jong-Hoon Kim, Jae Youl Cho. Mycetia cauliflora methanol extract exerts anti-inflammatory activity by directly targeting PDK1 in the NF-κB pathway. Journal of Ethnopharmacology 2019;231:1
    https://doi.org/10.1016/j.jep.2018.11.013
  46. Nannan Li, Guoxin Lin, Hao Zhang, Jian Sun, Ming Gui, Yan Liu, Wei Li, Jishi Liu, Juan Tang. Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury. Biomolecules 2022;12:984
    https://doi.org/10.3390/biom12070984
  47. Mi Seon Kim, Byong Chul Yoo, Woo Seok Yang, Sang Yun Han, Deok Jeong, Jun Min Song, Kyung Hee Kim, Adithan Aravinthan, Ji Hye Kim, Jong-Hoon Kim, Seung Cheol Kim, Jae Youl Cho. Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action. Oncotarget 2018;9:5979
    https://doi.org/10.18632/oncotarget.23192
  48. Han Gyung Kim, Mi-Yeon Kim, Jae Youl Cho. Alisma canaliculatum ethanol extract suppresses inflammatory responses in LPS-stimulated macrophages, HCl/EtOH-induced gastritis, and DSS-triggered colitis by targeting Src/Syk and TAK1 activities. Journal of Ethnopharmacology 2018;219:202
    https://doi.org/10.1016/j.jep.2018.03.022
  49. Dharambir Kashyap, Ajay Sharma, Katrin Sak, Hardeep Singh Tuli, Harpal Singh Buttar, Anupam Bishayee. Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy. Life Sciences 2018;194:75
    https://doi.org/10.1016/j.lfs.2017.12.005
  50. Jae Gwang Park, Young-Jin Son, Byong Chul Yoo, Woo Seok Yang, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho. Syk Plays a Critical Role in the Expression and Activation of IRAK1 in LPS-Treated Macrophages. Mediators of Inflammation 2017;2017:1
    https://doi.org/10.1155/2017/1506248
  51. Jie Shen, Jianying Shan, Lichao Zhong, Boying Liang, Dake Zhang, Motao Li, Hao Tang. Dietary Phytochemicals that Can Extend Longevity by Regulation of Metabolism. Plant Foods Hum Nutr 2022;77:12
    https://doi.org/10.1007/s11130-021-00946-z
  52. Young-Su Yi, Mi-Yeon Kim, Jae Youl Cho. JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38. Korean J Physiol Pharmacol 2017;21:345
    https://doi.org/10.4196/kjpp.2017.21.3.345
  53. Chaoran Song, Yo Han Hong, Jae Gwang Park, Han Gyung Kim, Deok Jeong, Junsang Oh, Gi-Ho Sung, Mohammad Amjad Hossain, Amani Taamalli, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho. Suppression of Src and Syk in the NF-κB signaling pathway by Olea europaea methanol extract is leading to its anti-inflammatory effects. Journal of Ethnopharmacology 2019;235:38
    https://doi.org/10.1016/j.jep.2019.01.024
  54. Wei Yu, Yaping Zhao, Iqra Ilyas, Li Wang, Peter J Little, Suowen Xu. The natural polyphenol fisetin in atherosclerosis prevention: a mechanistic review. 2024
    https://doi.org/10.1093/jpp/rgae053