Biomolecules & Therapeutics 2021; 29(2): 105~247
Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine
Stephen T. Deyrup, Natalie C. Stagnitti, Mackenzie J. Perpetua and Siu Wah Wong-Deyrup
Biomolecules & Therapeutics 2021; 29(2): 105-126  
Original Articles
Antineuroinfl ammatory Eff ects of 7,3’,4’-Trihydroxyisofl avone in Lipopolysaccharide-Stimulated BV2 Microglial Cells through MAPK and NF-κB Signaling Suppression
Seon-Kyung Kim, Yong-Hyun Ko, Youyoung Lee, Seok-Yong Lee and Choon-Gon Jang
Biomolecules & Therapeutics 2021; 29(2): 127-134  
Gene Expression Profiling in the Striatum of Per2 KO Mice Exhibiting More Vulnerable Responses against Methamphetamine
Mikyung Kim, Se Jin Jeon, Raly James Custodio, Hyun Jun Lee, Leandro Val Sayson, Darlene Mae D. Ortiz, Jae Hoon Cheong and Hee Jin Kim
Biomolecules & Therapeutics 2021; 29(2): 135-143  
Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells
Minji Bang, Edson Luck Gonzales, Chan Young Shin and Kyoung Ja Kwon
Biomolecules & Therapeutics 2021; 29(2): 144-153  
Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells
Hyunyee Yoon, Ji Hyun Sung and Moon Jung Song
Biomolecules & Therapeutics 2021; 29(2): 154-165  
A Novel Anti-PD-L1 Antibody Exhibits Antitumor Eff ects on Multiple Myeloma in Murine Models via Antibody-Dependent Cellular Cytotoxicity
Jae-Hee Ahn, Byung-Hyun Lee, Seong-Eun Kim, Bo-Eun Kwon, Hyunjin Jeong, Jong Rip Choi, Min Jung Kim, Yong Park, Byung Soo Kim, Dae Hee Kim and Hyun-Jeong Ko
Biomolecules & Therapeutics 2021; 29(2): 166-174  
Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption
Zhenling Zhang, Qiuping Zhang, Fang Li, Yi Xin and Zhijun Duan
Biomolecules & Therapeutics 2021; 29(2): 175-183  
KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells
Huihui Zhu, Yong Wang, Tao Wei, Xiaoming Zhao, Fuqiang Li, Yana Li, Fei Wang, Yong Cai and Jingji Jin
Biomolecules & Therapeutics 2021; 29(2): 184-194  
Endoplasmic Reticulum Stress-Mediated p62 Downregulation Inhibits Apoptosis via c-Jun Upregulation
Wenjun Yu, Busong Wang, Liang Zhou and Guoqiang Xu
Biomolecules & Therapeutics 2021; 29(2): 195-204  
Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress
Minjeong Kim, Eugenia Jin Lee and Kyung-Min Lim
Biomolecules & Therapeutics 2021; 29(2): 205-210  
Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells
Youn Kyung Choi, Jung-Il Kang, Jin Won Hyun, Young Sang Koh, Ji-Hoon Kang, Chang-Gu Hyun, Kyung-Sup Yoon, Kwang Sik Lee, Chun Mong Lee, Tae Yang Kim, Eun-Sook Yoo and Hee-Kyoung Kang
Biomolecules & Therapeutics 2021; 29(2): 211-219  
Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging
Youn Jin Kim, Ji Eun Lee, Hye Sung Jang, Sung Yun Hong, Jun Bae Lee, Seo Yeon Park and Jae Sung Hwang
Biomolecules & Therapeutics 2021; 29(2): 220-226  
Mechanisms of Resorcinol Antagonism of Benzo[a]pyrene-Induced Damage to Human Keratinocytes
Seung Eun Lee, Kitae Kwon, Sae Woong Oh, Se Jung Park, Eunbi Yu, Hyeyoun Kim, Seyoung Yang, Jung Yoen Park, Woo-Jae Chung, Jae Youl Cho and Jongsung Lee
Biomolecules & Therapeutics 2021; 29(2): 227-233  
Systematic Target Screening Revealed That Tif302 Could Be an Off -Target of the Antifungal Terbinafi ne in Fission Yeast
Sol Lee, Miyoung Nam, Ah-Reum Lee, Jaewoong Lee, Jihye Woo, Nam Sook Kang, Anand Balupuri, Minho Lee, Seon-Young Kim, Hyunju Ro, Youn-Woong Choi, Dong-Uk Kim and Kwang-Lae Hoe
Biomolecules & Therapeutics 2021; 29(2): 234-247  


Possible Effects of Radiofrequency Electromagnetic Field Exposure on Central Nerve System
Ju Hwan Kim, Jin-Koo Lee, Hyung-Gun Kim, Kyu-Bong Kim, and Hak Rim Kim
Received: August 7, 2018; Revised: November 1, 2018; Accepted: November 6, 2018
Flavonoids: Broad Spectrum Agents on Chronic Inflammation
Hyun Lim, Moon Young Heo, and Hyun Pyo Kim
Received: February 21, 2019; Revised: April 2, 2019; Accepted: April 4, 2019
Poncirin Inhibits Osteoclast Differentiation and Bone Loss through Down-Regulation of NFATc1 In Vitro and In Vivo
Kwang-Hoon Chun, Hyun Chul Jin, Ki Sung Kang, Tong-Shin Chang and Gwi Seo Hwang
Received: November 5, 2018; Revised: January 24, 2019; Accepted: April 3, 2019

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