Biomol Ther  
Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans
Eun Byeol Lee1, Jun Hyeong Kim1, Chang Wan An1, Yeong Jee Kim1, Yun Jeong Noh1, Su Jin Kim1, Ju-Eun Kim1, Abinash Chandra Shrestha1, Ha-Neul Ham1, Jae-Yoon Leem1, Hyung-Kwon Jo2, Dae-Sung Kim2, Kwang Hyun Moon3, Jeong Ho Lee3, Kyung Ok Jeong3 and Dae Keun Kim1,*
1College of Pharmacy, Woosuk University, Jeonju 55338, 2Hanpoong Pharm. Co., LTD, Wanju 55336, 3Sunchang Research Institute of Health and Longevity, Sunchang 56015, Republic of Korea
E-mail: dkkim@woosuk.ac.kr
Tel: +82-63-290-1574, Fax: +82-63-290-1812
Received: October 20, 2017; Revised: December 22, 2017; Accepted: January 19, 2018; Published online: March 14, 2018.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans, and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
Keywords: Zingiber officinale Roscoe, 6-Gingerol, Caenorhabditis elegans, Longevity, Stress tolerance


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