Biomol Ther  
Metabolic Signaling to Epigenetic Alterations in Cancer
Jung-Ae Kim1,3,* and Young Il Yeom2,3,*
1Personalized Genomic Medicine Research Center, 2Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, 3Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon 34113, Republic of Korea
E-mail: jungaekim@kribb.re.kr (Kim JA), yeomyi@kribb.re.kr (Yeom YI)
Tel: +82-42-879-8129 (Kim JA), +82-42-860-4109 (Yeom YI)
Fax: +82-42-879-8119 (Kim JA), +82-42-879-8119 (Yeom YI)
Received: September 15, 2017; Revised: October 19, 2017; Accepted: November 1, 2017; Published online: December 7, 2017.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Cancer cells reprogram cellular metabolism to support the malignant features of tumors, such as rapid growth and proliferation. The cancer promoting effects of metabolic reprogramming are found in many aspects: generating additional energy, providing more anabolic molecules for biosynthesis, and rebalancing cellular redox states in cancer cells. Metabolic pathways are considered the pipelines to supply metabolic cofactors of epigenetic modifiers. In this regard, cancer metabolism, whereby cellular metabolite levels are greatly altered compared to normal levels, is closely associated with cancer epigenetics, which is implicated in many stages of tumorigenesis. In this review, we provide an overview of cancer metabolism and its involvement in epigenetic modifications and suggest that the metabolic adaptation leading to epigenetic changes in cancer cells is an important non-genetic factor for tumor progression, which cooperates with genetic causes. Understanding the interaction of metabolic reprogramming with epigenetics in cancers may help to develop novel or highly improved therapeutic strategies that target cancer metabolism.
Keywords: Cancer, Metabolism, Epigenetics, Acetylation, Methylation, Metastasis


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