Biomolecules & Therapeutics  
Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-L-Methionine
Ki Taek Kim1, Ji Su Kim1, Min-Hwan Kim1, Ju-Hwan Park1, Jae-Young Lee1, WooIn Lee1, Kyung Kuk Min 2,
Min Gyu Song2, Choon-Young Choi2, Won-Serk Kim3, Hee Kyung Oh4 and Dae-Duk Kim1,*
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826,
2CUSKIN Cosmeceutical and Biotechnology, Seoul 06530,
3Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181,
4Department of Food and Nutrition, Jangan University, Hwaseong 18331, Republic of Korea
E-mail: ddkim@snu.ac.kr
Tel: +82-2-880-7870, Fax: +82-2-873-9177
Received: November 15, 2016; Revised: January 12, 2017; Accepted: January 14, 2017; Published online: March 10, 2017.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
S-methyl-L-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of -3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for the in vitro skin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect. Moreover, the combination of oleic acid and ethanol further enhanced in vitro permeation and deposition of SMM through hairless mouse skin. Furthermore, the combination of oleic acid and ethanol significantly increased the in vivo deposition of SMM in the epidermis/dermis for 12 hr, which was high enough to exert a therapeutic effect. Therefore, based on the in vitro and in vivo studies, the combination of oleic acid and ethanol was shown to be effective in improving the topical skin delivery of SMM, which may be applied in the cosmetic production process for SMM.
Keywords: S-methyl-L-methionine, Vitamin U, Skin permeation, Deposition, Enhancers


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