Biomolecules & Therapeutics  
Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases
Xiong Xiao1, Hui-Xia Liu1,2, Kuo Shen2, Wei Cao3 and Xiao-Qiang Li1,*
1Department of Pharmacology, School of Pharmacy, 2Cadet Brigade, 3Department of Natural Medicine & Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China
E-mail: xxqqli@fmmu.edu.cn

Tel: +86-29-84774556, Fax: +86-29-84774556
Received: May 9, 2016; Revised: December 4, 2016; Accepted: December 27, 2016; Published online: March 10, 2017.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of Ca2+ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions such as contraction, relaxation, proliferation, and dysfunction. This review, organized into seven main sections, will provide an overview of current knowledge about the underlying pathogenesis of TRPCs in cardio/cerebrovascular diseases, including hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury. Collectively, TRPCs could become a group of drug targets with important physiological functions for the therapy of human cardio/cerebro-vascular diseases.
Keywords: Ca2+ signaling, Canonical transient receptor potential receptor, Cardiovascular disease, Cerebrovascular disease, Pathogenesis


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