Biomolecules & Therapeutics  
Potential for Dependence on Lisdexamfetamine - in vivo and in vitro Aspects
Jaesuk Yun, Kwang-Wook Lee, Jang-Hyeon Eom, Young-Hoon Kim, Jisoon Shin, Kyoungmoon Han, Hye-Kyung Park, Hyung Soo Kim and Hye Jin Cha*
Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 28159, Republic of Korea
E-mail: chahj1@korea.kr
Tel: +82-43-719-5204, Fax: +82-43-719-5200
Received: April 7, 2016; Revised: October 30, 2016; Accepted: November 15, 2016; Published online: February 13, 2017.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Although lisdexamfetamine is used as a recreational drug, little research exists regarding its potential for dependence or its precise mechanisms of action. This study aims to evaluate the psychoactivity and dependence profile of lisdexamfetamine using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques are used to assess alterations in the dopamine levels in striatal synaptosomes following administration of lisdexamfetamine. Lisdexamfetamine increased both conditioned place preference and self-administration. Moreover, after administration of the lisdexamfetamine, dopamine levels in the striatal synaptosomes were significantly increased. Although some modifications should be made to the analytical methods, performing high performance liquid chromatography studies on synaptosomes can aid in predicting dependence liability when studying new psychoactive substances in the future. Collectively, lisdexamfetamine has potential for dependence possible via dopaminergic pathway.
Keywords: Lisdexamfetamine, Dependence, Conditioned place preference, Self-administration, Synaptosome, Dopamine


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