Biomolecules & Therapeutics 2009; 17(1): 62-69  
Suppressive Actions of Astragali Radix (AR) Ethanol Extract and Isolated Astragaloside I on HCl/ethanol-Induced Gastric Lesions
Jeong Suk JEONG1, Je-Hyuk LEE2, Sang Hyup LEE1, Sam Sik KANG3, and Choon Sik JEONG1,*
1College of Pharmacy, 2Plant Resources Research Institute, Duksung Women's University, Seoul 132-714, 3College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea
Received: December 30, 2008; Revised: November 26, 2008; Accepted: December 26, 2008; Published online: January 31, 2009.
© The Korean Society of Applied Pharmacology. All rights reserved.

Roots of Astragalus membranaceus (A. membranaceus) (Astragali Radix, AR) has been used as a herbal medicine for gastrointestinal disorders in China, Korea, Japan, and other Asia countries. In this study we investigated the effects of the AR 70% ethanol extract and compounds isolated from AR on gastritis in rats and growth of human gastric cancer cells. AR 70% ethanol extract showed the potent acid-neutralizing capacities and partly cytotoxicity of Helicobacter pylori and human AGS gastric cancers cell. Astragaloside I and daucosterol, which were isolated from AR, significantly inhibited HCl/ethanol-induced gastric lesions. In addition, daucosterol increased the mucus content to almost the same as the positive control. The results of this study suggest that astragaloside I and daucosterol may be good candidates for the development of new drugs or neutraceuticals which can be used for the treatment or prevention of gastritis.
Keywords: Astragalus membranaceus, Astragali Radix (AR), Astragaloside I, Gastritis, Helicobacter pylori

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