Biomol Ther (Seoul)  
Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders
Hyun Pyo Kim*, Hyun Lim and Yong Soo Kwon
College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea
E-mail: hpkim@kangwon.ac.kr
Tel: +82-33-250-6915, Fax: +82-33-255-7865
Received: August 18, 2016; Revised: September 21, 2016; Accepted: October 4, 2016; Published online: December 16, 2016.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription factor-κB activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.
Keywords: Medicinal plant, Lung inflammation, COPD, Constituent, Flavonoid


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