Biomol Ther (Seoul)  
Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs
Eun-Kyung Shin1, Hanseul Park2, Ji-Yoon Noh3,*, Kyung-Min Lim2,* and Jin-Ho Chung1
1College of Pharmacy, Seoul National University, Seoul 08826,
2College of Pharmacy, Ewha Womans University, Seoul 03760,
3Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
E-mail: kmlim@ewha.ac.kr (Lim KM), nohj16@kribb.re.kr (Noh JY)
Tel: +82-2-3277-3055 (Lim KM), +82-42-860-4655(Noh JY)
Fax: +82-2-3277-3760 (Lim KM), +82-42-879-8239 (Noh JY)
Received: June 27, 2016; Revised: August 27, 2016; Accepted: September 1, 2016; Published online: November 25, 2016.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. Upon exposure to physical or biochemical stimuli, remarkable platelet shape changes precede aggregation or adhesion. Platelets shape changes facilitate the formation and adhesion of platelet aggregates, but are readily reversible in contrast to the irrevocable characteristics of aggregation and adhesion. In this dynamic phenomenon, complex molecular signaling pathways and a host of diverse cytoskeleton proteins are involved. Platelet shape change is easily primed by diverse pro-thrombotic xenobiotics and stimuli, and its inhibition can modulate thrombosis, which can ultimately contribute to the development or prevention of thrombotic diseases. In this review, we discussed the current knowledge on the mechanisms of platelet shape change and also pathological implications and therapeutic opportunities for regulating the related cytoskeleton dynamics.
Keywords: Platelet shape changes, Cytoskeleton dynamics, Thrombosis, Aggregation, Adhesion


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