Biomolecules & Therapeutics 2008; 16(4): 343-350  
The Scutellaria Flavone, Oroxylin A, Improves Attention-Deficit/Hyperactivity Disorder Related Behaviors in Spontaneously Hypertensive Rats
Seo Young YOON5, Mi Sook CHUN5, Yong Soo LEE1, Hae Il PARK2, Chan Young SHIN3, Jong Hoon RYU4, and Jae Hoon CHEONG*
Uimyung Institute for Neuroscience, Sahmyook University, Seoul 139-742, Republic of Korea
1Department of Pharmacology College of Pharmacy, Duksung Women's University, Seoul 132-714, Republic of Korea
2College of Pharmacy, Kangwon National University, Chunchon 200-701, Republic of Korea
3Department of Pharmacology College of Medicine, Konkuk University, Seoul 143-701, Republic of Korea
4Department of Oriental Pharmaceutical Science College of Pharmacy, KyungHee University, Seoul 130-701, Republic of Korea
5Department of Pharmacy, Sahmyook University, 26-21, Kongreung 2-dong, Nowon-goo Seoul139-742 , Republic of Korea
Received: October 8, 2008; Revised: November 18, 2008; Accepted: November 21, 2008; Published online: December 31, 2008.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean medicine. In this study, we investigated the psychopharmacological activities of oroxylin A using the open field, rota-rod, balanced wire and plus-maze tests in Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto Rats (WKY). Oroxylin A reduced hyperactivity in SHR (ADHD animal model) although it tended to increase locomotor activity in WKY. Methylphenidate did not reduce hyperactivity. Oroxylin A alleviated impulsive behaviors such as rearing, the percentage of moving time to the central area and the tendency to move into an unstable condition (open area in elevated plus-maze). Methylphenidate also reduced the percentage of staying time in the central area and the tendency to move into an unstable condition. Both oroxylin A and methylphenidate enhanced motor attention in SHR and WKY. Oroxylin A antagonized the muscimol (GABAA receptor agonist)-induced Cl-current and its action was similar to that of bicuculline (GABAA receptor antagonist). The effects of oroxylin A may be caused by the antagonism at the GABAA receptor. Thus, oroxylin A may be a candidate of drug for treatment of ADHD.
Keywords: Scutellaria flavone, Behavior, Oroxylin A, ADHD, GABA


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