The Korean Society of Applied Pharmacology 2011; 19(2): 243-247  
Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
Young Min Seo1, Keumhan Noh1, Min Jeong Kong1, Dae Hun Lee1, Mi Jeong Kang1, Yurngdong Jahng1, Wonku Kang1, Byeong Seon Jeong1,* and Tae Cheon Jeong1,*
1College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea
Tae Cheon Jeong
Received: January 11, 2011; Revised: January 31, 2011; Accepted: January 31, 2011; Published online: April 30, 2011.
© The Korean Society of Applied Pharmacology. All rights reserved.

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Abstract
Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-infl ammatory. In the present study, a possible interaction between rutaecarpine and caffeine was investigated in male Sprague Dawley rats. Twenty four hr after the oral pretreatment with rutaecarpine at 80 mg/kg for three consecutive days, rats were treated intravenously with 10 mg/kg of caffeine. Compared with control rats, the pharmacokinetic parameters of caffeine in rutaecarpine-pretreated rats were signifi cantly changed, possibly due to the rapid metabolism. The production of three metabolites of caffeine (i.e., paraxanthine, theobromine and theophylline) was also signifi cantly changed in rats pretreated with rutaecarpine. The present results suggest that oral rutaecarpine would change the intravenous pharmacokinetic characteristics of caffeine.
Keywords: Rutaecarpine, Caffeine, Pharmacokinetics, Intravenous, Rat, In vivo


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