The Korean Society of Applied Pharmacology 2011; 19(1): 97-101  
Polyacetylene Compound from Cirsium japonicum var. ussuriense Inhibits the LPS-Induced Inflammatory Reaction via Suppression of NF-κB Activity in RAW 264.7 Cells
Tae Jin Kang1,3, Jung Sun Moon2,3, Sookyeon Lee2,3 and Dongsool Yim2,3,*
1Institute of Chronic Disease, 2Traditional Medicines Research Institute, 3College of Pharmacy, Sahmyook University, Seoul 139-742, Republic of Korea
Dongsool Yim
Received: August 16, 2010; Revised: October 16, 2010; Accepted: October 18, 2010; Published online: January 31, 2011.
© The Korean Society of Applied Pharmacology. All rights reserved.

Open Access
Abstract
Cirsium japonicum var. ussuriense is known to have a variety of biological activities, including anti-infl ammatory, analgesic activity and antipyretic activity. In this study we investigated the role of polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium japonicum var. ussuriense as an immune-modulator. PA was evaluated as inhibitors of some macrophage functions involved in the infl ammatory process. We tested the effect of PA on the production of pro-infl ammatory cyokines, interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) in murine macrophage cell line, RAW264.7. There was no effect on cytokine production of macrophages by PA itself. However, PA inhibited lipopolysaccharide (LPS)-induced IL-1β and TNF-α production by macrophages at a dose dependent manner. PA also suppressed the NO production of macrophages by LPS. LPS-induced NF-κB activity was decreased by treatment of PA. Therefore, these results suggest that PA has anti-infl ammatory effect by inhibiting the NF-κB activation.
Keywords: Polyacetylene compound, Cirsium japonicum var. ussuriense, Anti-infl ammatory activity, RAW264.7 cell


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