Biomolecules & Therapeutics 2008; 16(2): 132-136  
Anti-angiogenic, Anti-inflammatory and Anti-nociceptive Activities of Vanillin in ICR Mice
Eun-Ju LIM1, Hyun-Jung KANG2, Hyun-Joo JUNG1, Yun Seon SONG1, Chang-Jin LIM2, and Eun-Hee PARK1*
1College of Pharmacy, Sookmyung Women’s University, Seoul 140-742, Korea
2Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University, Chuncheon 200-701, Korea
Received: May 2, 2008; Accepted: June 13, 2008; Published online: June 1, 2008.
© The Korean Society of Applied Pharmacology. All rights reserved.

The current study aimed to assess some novel pharmacological activities of vanillin. Vanillin inhibited the chick chorioallantoic membrane (CAM) angiogenesis. Vanillin had anti-inflammatory activity using the acetic acid-induced permeability model in mice. Anti-nociceptive activity of vanillin was shown using the acetic acid-induced writhing test in mice. Vanillin inhibited production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) but not cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Vanillin decreased the level of iNOS mRNA in the LPS-activated macrophages. Taken together, these results suggest that vanillin can have anti-angiogenic, anti-inflammatory and anti-nociceptive activities in ICR Mice.
Keywords: vanillin, anti-angiogenic, anti-nociceptive, anti-inflammatory, nitric oxide

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