Biomolecules & Therapeutics  https://doi.org/10.4062/biomolther.2020.106
Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging
Youn Jin Kim1, Ji Eun Lee1, Hye Sung Jang1, Sung Yun Hong2, Jun Bae Lee2, Seo Yeon Park3 and Jae Sung Hwang1,*
1Department of Genetic Engineering & Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Youngin 17104,
2COSMAX R&I Center, Seongnam 13486,
3Creative & Innovation Center, IN2BIO, Hwaseong 18471, Republic of Korea
*E-mail: jshwang@khu.ac.kr
Tel: +82-31-201-3797, Fax: +82-31-203-4969
Received: June 11, 2020; Revised: August 21, 2020; Accepted: August 28, 2020; Published online: September 21, 2020.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
The role of particulate matter (PM) in health problems including cardiovascular diseases (CVD) and pneumonia is becoming increasingly clear. Polycyclic aromatic hydrocarbons, major components of PM, bind to aryl hydrocarbon receptor (AhRs) and promote the expression of CYP1A1 through the AhR pathway in keratinocytes. Activation of AhRs in skin cells is associated with cell differentiation in keratinocytes and inflammation, resulting in dermatological lesions. Oleanolic acid, a natural component of L. lucidum, also has anti-inflammation, anticancer, and antioxidant characteristics. Previously, we found that PM10 induced the AhR signaling pathway and autophagy process in keratinocytes. Here, we investigated the effects of oleanolic acid on PM10-induced skin aging. We observed that oleanolic acid inhibits PM10-induced CYP1A1 and decreases the increase of tumor necrosis factor– alpha and interleukin 6 induced by PM10. A supernatant derived from keratinocytes cotreated with oleanolic acid and PM10 inhibited the release of matrix metalloproteinase 1 in dermal fibroblasts. Also, the AhR-mediated autophagy disruption was recovered by oleanolic acid. Thus, oleanolic acid may be a potential treatment for addressing PM10-induced skin aging.
Keywords: PM, AhR, Oleanolic acid, TNF-α MMP-1, Autophagy


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