Biomolecules & Therapeutics  https://doi.org/10.4062/biomolther.2020.054
The Role of Leptin in the Association between Obesity and Psoriasis
Jaehyeon Hwang1,†, Ju Ah Yoo2,†, Hyungkee Yoon1,†, Taekyung Han1, Jongchan Yoon1, Seoljun An1, Jae Youl Cho3,* and Jongsung Lee2,*
1Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419,
2Molecular Dermatology Laboratory, Department of Integrative Biotechnology & Biocosmetics Research Center, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419,
3Molecular Immunology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
E-mail: bioneer@skku.edu (Lee J), jaecho@skku.edu (Cho JY)
Tel: +82-31-290-7861 (Lee J), +82-31-290-7868 (Cho JY)
Fax: +82-31-290-7870 (Lee J), +82-31-290-7870 (Cho JY)
The first three authors contributed equally to this work.
Received: April 8, 2020; Revised: June 17, 2020; Accepted: July 3, 2020; Published online: July 21, 2020.
© The Korean Society of Applied Pharmacology. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Adipose tissue secretes many adipokines which contribute to various metabolic processes, such as blood pressure, glucose homeostasis, inflammation and angiogenesis. The biology of adipose tissue in an obese individual is abnormally altered in a manner that increases the body’s vulnerability to immune diseases, such as psoriasis. Psoriasis is considered a chronic inflammatory skin disease which is closely associated with being overweight and obese. Additionally, secretion of leptin, a type of adipokine, increases dependently on adipose cell size and adipose accumulation. Likewise, high leptin levels also aggravate obesity via development of leptin resistance, suggesting that leptin and obesity are closely related. Leptin induction in psoriatic patients is mainly driven by the interleukin (IL)-23/helper T (Th) 17 axis pathway. Furthermore, leptin can have an effect on various types of immune cells such as T cells and dendritic cells. Here, we discuss the relationship between obesity and leptin expression as well as the linkage between effect of leptin on immune cells and psoriasis progression.
Keywords: Obesity, Psoriasis, Leptin, Adipose tissue, Pro-inflammatory cytokines


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