Recent Trends in Cyclic Peptides as Therapeutic Agents and Biochemical Tools
Joon-Seok Choi and Sang Hoon Joo*
College of Pharmacy, Daegu Catholic University, Gyeongsan 38430, Republic of Korea
E-mail: sjoo@cu.ac.kr
Tel: +82-53-850-3614, Fax: +82-53-359-6729
Received: May 17, 2019; Revised: August 9, 2019; Accepted: August 12, 2019; Published online: October 10, 2019.
© The Korean Society of Applied Pharmacology. All rights reserved.

Abstract
Notable progress has been made in the therapeutic and research applications of cyclic peptides since our previous review. New drugs based on cyclic peptides are entering the market, such as plecanatide, a cyclic peptide approved by the United States Food and Drug Administration in 2017 for the treatment of chronic idiopathic constipation. In this review, we examine recent developments in stapled peptides, prepared with the use of chemical linkers, and bicyclic/tricyclic peptides with more than two rings. These have widespread applications for clinical and research purposes: imaging, diagnostics, improvement of oral absorption, enzyme inhibition, development of receptor agonist/antagonist, and the modulation of protein-protein interaction or protein-RNA interaction. Many cyclic peptides are expected to emerge as therapeutics and biochemical tools.
Keywords: Cyclic peptides, Stapled peptides, Drug lead, Bicyclic peptide


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